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Gene Expression Data
Assay Details
Assay
Reference: J:335425 Derbyshire ML, et al., Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):1
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7482281
Gene symbol: Isl2
Gene name: insulin related protein 2 (islet 2)
Antibody: clone 39.4D5
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 6E: postnatal day 9; Tbx3tm3.1Moon/Tbx3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Present 6E
Specimen 6F: postnatal day 9; Tbx3tm3.1Moon/Tbx3tm3.1Moon, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Weak Regionally restricted 6F Significant decrease in retinal ganglion cells in dorsal retina, but no difference in ventral region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory