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Gene Expression Data
Assay Details
Assay
Reference: J:335425 Derbyshire ML, et al., Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):1
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7482280
Gene symbol: Opn4
Gene name: opsin 4 (melanopsin)
Antibody: anti-Melanopsin (AB-N38) (UF006)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 7D: postnatal day 9; Tbx3tm3.1Moon/Tbx3+ (more )
Structure Cell Type Level Pattern Image Note
TS28: retina retinal ganglion cell Present Regionally restricted 7D' , 7D Expression in differentiated intrinsically photosensitive retinal ganglion cells (ipRGCs).
Specimen 7E: postnatal day 9; Tbx3tm3.1Moon/Tbx3tm3.1Moon, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina retinal ganglion cell Weak Regionally restricted 7E' , 7E Significant reduction in ipRGC density in dorsal and nasal/temporal petals, but not in ventral petals.
Specimen 7G: postnatal day 30; Tbx3tm3.1Moon/Tbx3tm3.1Moon, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Weak Regionally restricted 7G , 7G' Difference persisted at P30.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory