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Gene Expression Data
Assay Details
Assay
Reference: J:335425 Derbyshire ML, et al., Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):1
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7482270
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: Secondary antibody
Results
Specimen S1F: postnatal day 20; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant. Triple labeled: blue - Pecam1 (CD31); green - Acta2 (assay MGI:7482269); red - Cre reporter.
Structure Level Pattern Image Note
TS28: retina blood vessel Present S1F' , S1F'''
Specimen S1G: postnatal day 20; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(Tek-cre)1Ywa/0 (more )
Note: Conditional mutant. Triple labeled: blue - Pecam1 (CD31); green - Acta2 (assay MGI:7482269); red - Cre reporter.
Structure Level Pattern Image Note
TS28: retina blood vessel Present S1G' , S1G'''
Specimen 3J: postnatal adult; Tbx3tm3.1Moon/Tbx3+ (more )
Note: Double labeled: red - Pecam1 (CD31); green - IB4 lectin.
Structure Level Pattern Image Note
TS28: retina blood vessel Present Regionally restricted 3J Expression in retinal plexus in dorsal retina. Normal tri-layered vasculature and interplexus branchings.
Specimen 3K: postnatal adult; Tbx3tm3.1Moon/Tbx3tm3.1Moon, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant. Double labeled: red - Pecam1 (CD31); green - IB4 lectin.
Structure Level Pattern Image Note
TS28: retina blood vessel Present Regionally restricted 3K Expression in retinal vasculatue lacking superficial plexus.
Specimen S3A: postnatal adult; Tbx3tm3.1Moon/Tbx3+ (more )
Structure Level Pattern Image Note
TS28: retina blood vessel Present Regionally restricted S3A Expression in dorsal retinal vasculature.
Specimen S3B: postnatal adult; Tbx3tm3.1Moon/Tbx3tm3.1Moon, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina blood vessel Present Regionally restricted S3B Retinal vasculature reduced in complexity compared to wild type.
Specimen 5D: postnatal day 10; Tbx3tm3.1Moon/Tbx3tm3.1Moon, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant. Double labeled: green - Pecam1 (CD31); orange - Gfap (assay MGI:7482276).
Structure Level Pattern Image Note
TS28: retina blood vessel Present Regionally restricted 5D'' , 5D''' Abnormal vascular plexus in areas without stereotypical astrocyte lattice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory