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Gene Expression Data
Assay Details
Assay
Reference: J:207609 Hilliard SA, et al., Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014 Mar 1;387(1):1-14
Assay type: RNA in situ
MGI Accession ID: MGI:7481342
Gene symbol: Wnt4
Gene name: wingless-type MMTV integration site family, member 4
Probe: Wnt4 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 7C: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: early nephron Present 7C

Specimen 7D: embryonic day 14.5; Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: early nephron Present 7D There were far fewer positive nascent nephrons (control kidneys have 3-fold more over the mutant kidneys).

Specimen S4E: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: early nephron Present S4E

Specimen S4F: embryonic day 13.5; Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: early nephron Present S4F Similar expression as in the control.

Specimen not shown: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: early nephron Present

Specimen not shown: embryonic day 15.5; Mdm2tm1.2Mep/Mdm2tm1.2Mep, Tg(Six2-GFP/cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: early nephron Present There were far fewer positive nascent nephrons.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory