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Gene Expression Data
Assay Details
Assay
Reference: J:333828 Blommers M, et al., Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11. Dev Dyn. 2023 Feb;252(2):305-319
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7469643
Gene symbol: Dcx
Gene name: doublecortin
Antibody: anti-DCX
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 1H/I: embryonic day 16.5; Cux2tm1.1(cre)Mull/Cux2+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Double labeled: yellow - Dcx; red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS24: retina layer retinal progenitor cell Present 1I , 1H Expressed in migratory neuroblasts in the basal layers and migrating neuroblasts in the neuroblastic cell layer.
Specimen 1K/L: embryonic day 18.5; Cux2tm1.1(cre)Mull/Cux2+, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Double labeled: yellow - Dcx; red - Cre reporter.
Structure Cell Type Level Pattern Image Note
TS26: retina layer retinal progenitor cell Present 1L , 1K Expressed in migratory neuroblasts in the basal layers and migrating neuroblasts in the neuroblastic cell layer.
TS26: retina ganglion cell layer retinal ganglion cell Present 1L , 1K
TS26: retina ganglion cell layer amacrine cell Present 1L , 1K Expressed in the displaced amacrine cells.
Specimen 5A/C/E: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: retina layer retinal progenitor cell Present Regionally restricted 5E , 5C , 5A Expressed in migratory neuroblasts with extensive bipolar cellular processes in the neuroblastic cell layer (in a more extensive distribution throughout) and cells in the ganglion cell layer.
TS26: retina ganglion cell layer retinal ganglion cell Present 5C , 5A , 5E
TS26: retina ganglion cell layer amacrine cell Present 5C , 5E , 5A Expressed in the displaced amacrine cells.
Specimen 5B/D/F: embryonic day 18.5; Mllt11tm1c(KOMP)Mbp/Mllt11tm1c(KOMP)Mbp, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Cux2tm1.1(cre)Mull/Cux2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: retina layer retinal progenitor cell Present Regionally restricted 5B , 5F , 5D Positive migratory neuroblasts with a more rounded multipolar morphologies were aberrantly localized in the apical region of the neuroblastic cell layer.
TS26: retina ganglion cell layer retinal ganglion cell Present 5B , 5D
TS26: retina ganglion cell layer amacrine cell Present 5B , 5D Expressed in the displaced amacrine cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory