About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:203791 Kuracha MR, et al., Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7464525
Gene symbol: Mapk1
Gene name: mitogen-activated protein kinase 1
Antibody: anti-p-ERK1/2
Assay notes: The antibody used recognizes the phosphorylated form of the protein. The specificity of the antibody used was not detailed; both family members have been annotated.
Results
Specimen 5E/E'/E": embryonic day 14.5 (more )
Note: upper eyelid
Structure Cell Type Level Pattern Image Note
TS22: upper eyelid peridermal cell Present 5E' , 5E
TS22: conjunctiva epithelium conjunctival epithelial cell Present 5E , 5E"
TS22: upper eyelid mesenchyme Present 5E
Specimen 5F/F'/F": embryonic day 14.5; Spry1tm1Jdli/Spry1tm1Jdli, Spry2tm1Mrt/Spry2tm1Mrt, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant. upper eyelid
Structure Cell Type Level Pattern Image Note
TS22: upper eyelid peridermal cell Present 5F' , 5F Similar expression as in the control.
TS22: conjunctiva epithelium conjunctival epithelial cell Present 5F , 5F" Increased expression in the palpebral and bulbar conjunctival cells compared with the control.
TS22: upper eyelid mesenchyme Present 5F Similar expression as in the control.
Specimen 5G/G'/G": embryonic day 14.5 (more )
Note: lower eyelid
Structure Cell Type Level Pattern Image Note
TS22: lower eyelid peridermal cell Present 5G' , 5G
TS22: conjunctiva epithelium conjunctival epithelial cell Present 5G , 5G"
TS22: lower eyelid mesenchyme Present 5G
Specimen 5H/H'/H": embryonic day 14.5; Spry1tm1Jdli/Spry1tm1Jdli, Spry2tm1Mrt/Spry2tm1Mrt, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant. lower eyelid
Structure Cell Type Level Pattern Image Note
TS22: lower eyelid peridermal cell Present 5H' , 5H Similar expression as in the control.
TS22: conjunctiva epithelium conjunctival epithelial cell Present 5H" , 5H Increased expression in the palpebral and bulbar conjunctival cells compared with the control.
TS22: lower eyelid mesenchyme Present 5H Similar expression as in the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory