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Gene Expression Data
Assay Details
Assay
Reference: J:173287 Long JE, et al., Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
Assay type: RNA in situ
MGI Accession ID: MGI:7464496
Gene symbol: Isl1
Gene name: ISL1 transcription factor, LIM/homeodomain
Probe: Islet1 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Assay notes: Table 4 data was incorporated into Fig. 7 & S2 samples, as per the text.
Results
Specimen 5o: embryonic day 15.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence mantle zone Strong 5o
TS23: lateral ganglionic eminence subventricular zone Strong 5o
TS23: olfactory tubercle Present 5o
Specimen 5o': embryonic day 15.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence mantle zone Strong Regionally restricted 5o' Expression remained strong in the dorsal and ventral lateral ganglionic eminence in the mutant.
TS23: lateral ganglionic eminence subventricular zone Strong Regionally restricted 5o' Expression remained strong in the dorsal and ventral lateral ganglionic eminence in the mutant.
TS23: olfactory tubercle Absent 5o'
Specimen 7d: embryonic day 15.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence Present S2j , 7d
TS23: telencephalon septum Present S2j , 7d
Specimen 7d': embryonic day 15.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence mantle zone Present 7d' Expression was moderately/mildly decreased in the subventricular zone and mantle zone.
TS23: lateral ganglionic eminence subventricular zone Present 7d' Expression was moderately/mildly decreased in the subventricular zone and mantle zone.
TS23: lateral ganglionic eminence ventricular zone Absent 7d'
TS23: telencephalon septum Present Regionally restricted 7d' Expression was increased in the mantle zone. Expression was severely decreased in the subventricular zone and undetectable in the ventricular zone.
Specimen 7d'': embryonic day 15.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence mantle zone Present Regionally restricted 7d'' , S2j'' Expression was increased in the dorsal subventricular zone and severely decreased in the ventral subventricular zone and ventral mantle zone.
TS23: lateral ganglionic eminence subventricular zone Present Regionally restricted 7d'' , S2j'' Expression was increased in the dorsal subventricular zone and severely decreased in the ventral subventricular zone and ventral mantle zone.
TS23: lateral ganglionic eminence ventricular zone Absent 7d'' , S2j''
TS23: telencephalon septum Weak Regionally restricted 7d'' , S2j'' Expression was severely decreased in the subventricular zone and mantle zone. It was undetectable in the ventricular zone.
Specimen 7d''': embryonic day 15.5; Ascl1tm1And/Ascl1tm1And, Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence mantle zone Weak Regionally restricted 7d''' Expression was increased in the mantle zone.
TS23: lateral ganglionic eminence subventricular zone Present 7d''' Expression was unchanged in the subventricular zone.
TS23: lateral ganglionic eminence ventricular zone Absent 7d'''
TS23: telencephalon septum Weak Regionally restricted 7d''' Expression was severely decreased in the subventricular zone and mantle zone. It was undetectable in the ventricular zone.
Specimen S2j': embryonic day 15.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence Present Regionally restricted S2j' Expression was moderately/mildly decreased in the subventricular zone and mantle zone. It was undetectable in the ventricular zone.
TS23: telencephalon septum Present Regionally restricted S2j' Expression was increased in the mantle zone. Expression was severely decreased in the subventricular zone and undetectable in the ventricular zone.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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