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Gene Expression Data
Assay Details
Assay
Reference: J:173287 Long JE, et al., Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
Assay type: RNA in situ
MGI Accession ID: MGI:7464471
Gene symbol: Ascl1
Gene name: achaete-scute family bHLH transcription factor 1
Probe: Mash1 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Assay notes: Table 4 data was incorporated into Fig. 7 &S2 samples, as per the text.
Results
Specimen 3k: embryonic day 15.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence Present Regionally restricted 3k Expression was detected in the ventricular zone and/or subventricular zone.
Specimen 3k': embryonic day 15.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence Present Regionally restricted 3k' Expression was upregulated in the lateral ganglionic eminence, particularly in the subventricular zone.
TS23: lateral ganglionic eminence subventricular zone Present 3k'
Specimen 7a: embryonic day 15.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS23: telencephalon septum Present S2b , 7a
TS23: lateral ganglionic eminence Present S2b , 7a
Specimen 7a': embryonic day 15.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Present Regionally restricted S2b' , 7a' Expression was unchanged in the ventricular zone. It was undetectable in the subventricular zone and mantle zone.
TS23: lateral ganglionic eminence subventricular zone Present Regionally restricted S2b' , 7a' Expression was increased.
TS23: lateral ganglionic eminence ventricular zone Present Regionally restricted S2b' , 7a' Expression was increased.
TS23: lateral ganglionic eminence mantle zone Absent 7a' , S2b'
Specimen 7a'': embryonic day 15.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Present Regionally restricted S2b'' , 7a'' Expression was severely decreased in the ventricular zone and undetectable in the subventricular zone and mantle zone.
TS23: lateral ganglionic eminence ventricular zone Present 7a'' , S2b'' Expression was unchanged.
TS23: lateral ganglionic eminence mantle zone Absent 7a'' , S2b''
TS23: lateral ganglionic eminence subventricular zone Absent 7a'' , S2b''
Specimen 7a''': embryonic day 15.5; Ascl1tm1And/Ascl1tm1And, Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Present Regionally restricted 7a''' Expression was unchanged in the ventricular zone and undetectable in the subventricular zone and mantle zone.
TS23: lateral ganglionic eminence ventricular zone Present 7a''' Expression was unchanged.
TS23: lateral ganglionic eminence subventricular zone Strong 7a''' Expression was increased in the subventricular zone.
TS23: lateral ganglionic eminence mantle zone Absent 7a'''
Specimen S1n: embryonic day 12.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence Present S1n
Specimen S1n': embryonic day 12.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence Present S1n' Expression was upregulated.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory