About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:203791 Kuracha MR, et al., Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
Assay type: RNA in situ
MGI Accession ID: MGI:7464148
Gene symbol: Spry1
Gene name: sprouty RTK signaling antagonist 1
Probe: Spry1 cDNA
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 1A: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: eye epithelium conjunctival epithelial cell Present 1A Palpebral and forniceal epithelial cells showed stronger expression than bulbar epithelial cells.
TS20: perioptic mesenchyme Present 1A
TS20: naso-lacrimal groove Present 1A nasolacrimal duct
Specimen 1D: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: conjunctiva epithelium conjunctival epithelial cell Present 1D Palpebral and forniceal epithelial cells showed stronger expression than bulbar epithelial cells.
TS22: eyelid epidermal cell Present Regionally restricted 1D Expressed in the palpebral epidermal cells.
TS22: eyelid mesenchyme Present Regionally restricted 1D Expression was more localized. Expression was stronger in the mesenchymal cells closer to the margin.
Specimen 1G/G': embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: conjunctiva epithelium conjunctival epithelial cell Present 1G Palpebral and forniceal epithelial cells showed stronger expression than bulbar epithelial cells.
TS23: eyelid epidermal cell Present Regionally restricted 1G Expressed in the palpebral epidermal cells.
TS23: eyelid mesenchyme Present Regionally restricted 1G' , 1G Expression was more localized. Expression was stronger in the mesenchymal cells closer to the margin.
TS23: periderm peridermal cell Present Regionally restricted 1G' Expressed in peridermal cells at the leading edge of the eyelid.
Specimen 1K: embryonic day 14.5; Spry1tm1Jdli/Spry1tm1Jdli, Spry2tm1Mrt/Spry2tm1Mrt, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: conjunctiva epithelium conjunctival epithelial cell Trace 1K Near complete loss of expression was seen.
TS22: conjunctival sac Present Regionally restricted 1K Increased expression in the bulbar mesenchymal cells compared with the control.
TS22: eyelid mesenchyme Present Regionally restricted 1K Increased expression in the mesenchymal cells adjacent to the bulbar and palpebral conjunctival epithelia compared with the control.
TS22: eyelid epidermal cell Trace Regionally restricted 1K Substantially reduced expression in the eyelid epidermal cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory