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Gene Expression Data
Assay Details
Assay
Reference: J:277247 Vetrivel S, et al., Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019 Apr 13;
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7461923
Gene symbol: Pou4f1
Gene name: POU domain, class 4, transcription factor 1
Antibody: anti-Brn-3 (C-13): sc-6026
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 10a C3H E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: retina Absent 10a C3H E11.5

Specimen 10a Aey69 E11.5: embryonic day 11.5; Gja8Aey69/Gja8Aey69, H3c14Aey69/H3c14Aey69 (more )
Structure Level Pattern Image Note
TS19: retina Present 10a Aey69 E11.5 Early expression in retinal cells compared to wild type.

Specimen 10a C3H E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: retina Present Regionally restricted 10a C3H E12.5 Expression in central retina.

Specimen 10a Aey69 E12.5: embryonic day 12.5; Gja8Aey69/Gja8Aey69, H3c14Aey69/H3c14Aey69 (more )
Structure Level Pattern Image Note
TS20: retina Present 10a Aey69 E12.5 More expressing cells compared to wild type.

Specimen 10a C3H E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: retina Present Regionally restricted 10a C3H E13.5 Expansion of expression to peripheral retinal regions.

Specimen 10a Aey69 E13.5: embryonic day 13.5; Gja8Aey69/Gja8Aey69, H3c14Aey69/H3c14Aey69 (more )
Structure Level Pattern Image Note
TS21: retina Present 10a Aey69 E13.5 More expressing cells compared to wild type.

Specimen 10a C3H E15.5: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: retina retinal ganglion cell Present Regionally restricted 10a C3H E15.5 Expression extends to migrating retinal ganglion cells to form the prospective ganglion cell layer

Specimen 10a Aey69 E15.5: embryonic day 15.5; Gja8Aey69/Gja8Aey69, H3c14Aey69/H3c14Aey69 (more )
Structure Cell Type Level Pattern Image Note
TS23: retina retinal ganglion cell Present Regionally restricted 10a Aey69 E15.5 Expansion of expressing cells migrating to prospective ganglion cell layer similar to that of wild type.

Specimen 11a BRN3 C3H: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Present 11a C3H BRN3

Specimen 11a BRN3 Aey69: postnatal day 7; Gja8Aey69/Gja8Aey69, H3c14Aey69/H3c14Aey69 (more )
Structure Level Pattern Image Note
TS28: eye Present Widespread 11a Aey69 BRN3 Expression covering entire 'empty lens area' of mutant eye.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory