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Gene Expression Data
Assay Details
Assay
Reference: J:311215 Fazilaty H, et al., Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage. Cell Rep. 2021 Aug 3;36(5):109484
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7461505
Gene symbol: Pdgfra
Gene name: platelet derived growth factor receptor, alpha polypeptide
Reporter: GFP
Direct Detection
Results
Specimen 1A - E14.5: embryonic day 14.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Structure Level Pattern Image Note
TS22: hindgut mesenchyme Present 1A E14.5 No crypt-like structures are visible at this age.
Specimen 1A - E15.5: embryonic day 15.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Structure Level Pattern Image Note
TS23: hindgut mesenchyme Present 1A E15.5 Cells begin to reorganize at this time.
Specimen 1A - E16.5: embryonic day 16.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Structure Level Pattern Image Note
TS24: hindgut mesenchyme Present 1A E16.5
Specimen 1A - E17.5: embryonic day 17.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Structure Level Pattern Image Note
TS25: hindgut mesenchyme Present 1A E17.5
Specimen 1A - E18.5: embryonic day 18.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Structure Level Pattern Image Note
TS26: hindgut mesenchyme Present Non-Uniform 1A E18.5 Crypts are clearly discernible at this age. Higher expressing cells are near the top of the invaginations and lower expressing cells near the bottom.
Specimen 1A - Adult: postnatal adult; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Structure Level Pattern Image Note
TS28: large intestine crypt of lieberkuhn Present 1A Adult
Specimen 3G: embryonic day 18.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Double labeled: green - Pdgfra; magenta - Muc2 (assay MGI:7461523).
Structure Cell Type Level Pattern Image Note
TS26: hindgut mesenchyme fibroblast Present Single cells 3G , 3G inset 1 Expression is seen in fibroblasts at the crypt top region.
Specimen 4C - E14.5: embryonic day 14.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Triple labeled: green - Pdgfra; gray - Epcam (assay MGI:7461528); magenta - Apoa1 (assay MGI:7461521).
Structure Level Pattern Image Note
TS22: hindgut mesenchyme Present 4C E14.5 Center , 4C E14.5 Inset 1
Specimen 4C - E15.5: embryonic day 15.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Triple labeled: green - Pdgfra; gray - Epcam (assay MGI:7461528); magenta - Apoa1 (assay MGI:7461521).
Structure Level Pattern Image Note
TS23: hindgut mesenchyme Present 4C E15.5 Center , 4C E15.5 Inset 2
Specimen 4C - E18.5: embryonic day 18.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Triple labeled: green - Pdgfra; gray - Epcam (assay MGI:7461528); magenta - Apoa1 (assay MGI:7461521).
Structure Level Pattern Image Note
TS26: hindgut mesenchyme Present 4C E18.5 Inset 3 , 4C E18.5 Center
Specimen 4C - Adult: postnatal adult; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Triple labeled: green - Pdgfra; gray - Epcam (assay MGI:7461528); magenta - Apoa1 (assay MGI:7461521).
Structure Level Pattern Image Note
TS28: large intestine crypt of lieberkuhn Present 4C Adult healthy Inset 4 , 4C Adult healthy Center
Specimen S4B - E14.5: embryonic day 14.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Transverse section.
Structure Level Pattern Image Note
TS22: hindgut mesenchyme Present S4B E14.5
Specimen S4B - E15.5: embryonic day 15.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Transverse section.
Structure Level Pattern Image Note
TS23: hindgut mesenchyme Present S4B E15.5
Specimen S4B - E18.5: embryonic day 18.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Transverse section.
Structure Level Pattern Image Note
TS26: hindgut mesenchyme Present Non-Uniform S4B E18.5 Crypts are clearly discernible at this age. Higher expressing cells are near the top of the invaginations and lower expressing cells near the bottom.
Specimen S4C: embryonic day 18.5; Pdgfratm11(EGFP)Sor/Pdgfra+ (more )
Note: Transverse section.
Structure Cell Type Level Pattern Image Note
TS26: hindgut mesenchyme fibroblast Present S4C Expression is seen in fibroblasts at the crypt top region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory