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Gene Expression Data
Assay Details
Assay
Reference: J:332883 Rastegar-Pouyani S, et al., Somatotopy of Mouse Spinothalamic Innervation and the Localization of a Noxious Stimulus Requires Deleted in Colorectal Carcinoma Expression by Phox2a Neurons. J Neurosci. 2022 Oct 19;42(42):7885-7899
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7450999
Gene symbol: Dcc
Gene name: DCC netrin 1 receptor
Antibody: anti-DCC (AF844)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A control: embryonic day 10.5 (more )
Note: Double labeled: green - Dcc; red - Phox2a (assay MGI:7450997).
Structure Level Pattern Image Note
TS17: future spinal cord Present 1A control merge , 1A control DCC Expressed in essentially all first-born Phox2a+ neurons.
Specimen 1A cKO: embryonic day 10.5; Dcctm1Nki/Dcctm1Nki, Tg(Phox2a-cre)1Kania/0 (more )
Note: Conditional mutant. Double labeled: green - Dcc; red - Phox2a (assay MGI:7450997).
Structure Level Pattern Image Note
TS17: future spinal cord Present Regionally restricted 1A cKO merge , 1A cKO DCC Loss of expression in Phox2a+ neurons.
Specimen 6D/D': embryonic day 15.5; Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(CDX2-flpo)#Gld/0, Tg(Phox2a-cre)1Kania/0 (more )
Note: Conditional mutant. Double labeled: green - Dcc; red - Cre reporter.
Structure Level Pattern Image Note
TS23: spinal cord Present Regionally restricted 6D DCC , 6D' Expressed in the anterolateral tract, and coexpressed with tdTomato.
Specimen 6E/E': embryonic day 15.5; Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Tg(CDX2-flpo)#Gld/0, Tg(Phox2a-cre)1Kania/0 (more )
Note: Conditional mutant. Double labeled: green - Dcc; red - Cre reporter.
Structure Level Pattern Image Note
TS23: thalamus Present 6E' , 6E Some of positive axons coexpressed tdTomato.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
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