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Gene Expression Data
Assay Details
Assay
Reference: J:225747 Jayewickreme CD, et al., Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 1;405(1):21-32
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7448896
Gene symbol: Acta2
Gene name: actin alpha 2, smooth muscle, aorta
Antibody: anti-SMA-A
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 4A control stomach: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: stomach lamina propria smooth muscle cell Present 4A lower left
TS25: stomach wall smooth muscle cell Present 4A lower left
Specimen 4A control intestine: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: intestine lamina propria enteric smooth muscle cell Present 4A lower middle
TS25: intestine smooth muscle enteric smooth muscle cell Present 4A lower middle
Specimen 4A Ins intestine: embryonic day 17.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS25: intestine lamina propria enteric smooth muscle cell Present 4A lower right Significant smooth muscle expansion was seen.
TS25: intestine smooth muscle enteric smooth muscle cell Present 4A lower right Significant smooth muscle expansion was seen.
Specimen 4B: embryonic day 17.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS25: intestine smooth muscle enteric smooth muscle cell Present 4B Smooth muscle was expanded throughout the intestinal length and uniformly around the perimeter.
Specimen 4C: embryonic day 17.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS25: intestine smooth muscle enteric smooth muscle cell Present 4C Focal hypertrophy was seen.
Specimen 4D: embryonic day 17.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS25: intestine smooth muscle enteric smooth muscle cell Strong 4D Smooth muscle expansion was seen.
TS25: pancreas parenchyma Weak 4D Similar as in the control.
Specimen 4G control: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: intestine smooth muscle enteric smooth muscle cell Present 4G upper right , 4G upper left
Specimen 4G Int: embryonic day 14.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: intestine smooth muscle enteric smooth muscle cell Present 4G lower left , 4G lower right Similar as in the control.
Specimen 4H control: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: intestine smooth muscle enteric smooth muscle cell Present 4H upper right , 4H upper left
Specimen 4H Int: embryonic day 15.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS23: intestine smooth muscle enteric smooth muscle cell Present 4H lower left , 4H lower right Increased levels of muscle compared with the control.
Specimen 4I control: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: intestine smooth muscle enteric smooth muscle cell Present 4I upper
Specimen 4I Int: embryonic day 16.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS24: intestine smooth muscle enteric smooth muscle cell Present 4I lower Increased levels of muscle compared with the control.
Specimen S1C control: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: stomach pyloric region muscularis smooth muscle cell Present S1C left
Specimen S1C Int: embryonic day 17.5; Gt(ROSA)26Sortm1(Barx1)Shiv/Gt(ROSA)26Sor+, Nkx3-2tm1(cre)Wez/Nkx3-2+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS25: stomach pyloric region muscularis smooth muscle cell Present S1C right No hypertrophy was seen.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
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