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Gene Expression Data
Assay Details
Assay
Reference: J:237224 Kim JY, et al., Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye. Dev Biol. 2016 Nov 15;419(2):336-347
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7437600
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Antibody: Anti-OTX2 (AB9566)
Detection system: Secondary antibody coupled to Cy5
Results
Specimen 4A: embryonic day 16.5; Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Structure Cell Type Level Pattern Image Note
TS24: pigmented retinal epithelium retinal pigment epithelial cell Present 4A Regularly spaced, single-layered arrangement.
TS24: neural retina Present Regionally restricted 4A Expressed in an apically-enriched, scattered pattern in the outer neuroblastic layer.
Specimen 4B: embryonic day 16.5; Tg(rx3-icre)1Mjam/0, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: pigmented retinal epithelium Present Regionally restricted 4B Abrupt loss of expression was evident in regions where a multi-cell layered epithelium was forming. The expression pattern within the pseudostratified epithelium was similar to that of normal retina, but apical concentration was lost.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory