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Gene Expression Data
Assay Details
Assay
Reference: J:294897 Ankamreddy H, et al., CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development. Dev Dyn. 2020 Sep;249(9):1117-1126
Assay type: RNA in situ
MGI Accession ID: MGI:7435180
Gene symbol: Cxcl12
Gene name: C-X-C motif chemokine ligand 12
Probe: Cxcl12 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme derived from neural crest Weak Regionally restricted 1C Weak expression was detected in the mesenchyme, lateral to the pharyngeal mesenchyme, and partially overlapped with the developing malleus-incus.
TS17: middle ear mesenchyme Weak Regionally restricted 1C Weak expression was detected in the mesenchyme, lateral to the pharyngeal mesenchyme, and partially overlapped with the developing malleus-incus.
Specimen 1F: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: 1st branchial arch mesenchyme derived from neural crest Weak Regionally restricted 1F Weak expression was detected in the mesenchyme, lateral to the pharyngeal mesenchyme, and partially overlapped with the developing malleus-incus.
TS18: middle ear mesenchyme Weak Regionally restricted 1F Weak expression was detected in the mesenchyme, lateral to the pharyngeal mesenchyme, and partially overlapped with the developing malleus-incus.
Specimen 1I: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: 1st branchial arch Present Regionally restricted 1I By E11.5, the expression domain no longer overlapped with the developing malleus-incus.
Specimen 1M: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 2nd branchial arch mesenchyme derived from neural crest Present Regionally restricted 1M In pharyngeal arch 2, the expression domain overlaps with stapedial condensation.
TS17: middle ear mesenchyme Present Regionally restricted 1M In pharyngeal arch 2, the expression domain overlaps with stapedial condensation.
Specimen 1P: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: 2nd branchial arch mesenchyme derived from neural crest Present Regionally restricted 1P In pharyngeal arch 2, the expression domain overlaps with stapedial condensation.
TS18: middle ear mesenchyme Present Regionally restricted 1P In pharyngeal arch 2, the expression domain overlaps with stapedial condensation.
Specimen 1S: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: 2nd branchial arch mesenchyme derived from neural crest Present Regionally restricted 1S In pharyngeal arch 2, the expression domain overlaps with stapedial condensation.
TS19: middle ear mesenchyme Present Regionally restricted 1S In pharyngeal arch 2, the expression domain overlaps with stapedial condensation.
Specimen 1W: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: ossicle pre-cartilage condensation Weak Regionally restricted 1W Cxcl12 was not expressed in the malleus and incus condensations and was decreased in stapes condensation.
Specimen 1Z: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: stapes pre-cartilage condensation Trace 1Z
Specimen 4D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: middle ear mesenchyme Present Regionally restricted 4D Expression was detected in the prospective stapes region.
Specimen 4H: embryonic day 10.5; Bmp4tm1Blh/Bmp4tm4Blh, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: middle ear mesenchyme Present Regionally restricted 4H Expression was detected in the prospective stapes region of the conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory