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Gene Expression Data
Assay Details
Assay
Reference: J:333013 Huang T, et al., Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects. Gastroenterology. 2022 Jan;162(1):179-192.e11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7434130
Gene symbol: Ngfr
Gene name: nerve growth factor receptor (TNFR superfamily, member 16)
Results
Specimen 1A +/+: embryonic day 10.5 (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Present Regionally restricted 1Ai Expression in sacral neural crest cells along medial pathway and their pioneer (most ventrally located) cells.
Specimen 1A Dom/+: embryonic day 10.5; Sox10Dom/Sox10+ (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Weak Regionally restricted 1Aii Significant reduction of expression in pioneer sacral neural crest cells in periaortic area.
Specimen 1A Dom/Dom: embryonic day 10.5; Sox10Dom/Sox10Dom (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory neural crest cell Weak Regionally restricted 1Aiii Significant reduction of expression in pioneer sacral neural crest cells in periaortic area.
Specimen 1D +/+: embryonic day 11.5 (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS19: pelvic ganglion migratory neural crest cell Present Regionally restricted 1Di Expression in sacral neural crest cells lateral to hindgut.
Specimen 1D Dom/+: embryonic day 11.5; Sox10Dom/Sox10+ (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS19: pelvic ganglion migratory neural crest cell Present Regionally restricted 1Dii Expression in sacral neural crest cells lateral to hindgut.
Specimen 1D Dom/Dom: embryonic day 11.5; Sox10Dom/Sox10Dom (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Level Pattern Image Note
TS19: pelvic ganglion Absent 1Diii Neural crest cells not found in position of pelvic ganglion.
Specimen S2C +/+: embryonic day 12.5 (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS20: pelvic ganglion migratory neural crest cell Present Regionally restricted S2Ci Expression in sacral neural crest cells
Specimen S2C Dom/+: embryonic day 12.5; Sox10Dom/Sox10+ (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS20: pelvic ganglion migratory neural crest cell Weak Regionally restricted S2Cii Signficantly fewer sacral neural crest cells than in wildtype.
Specimen S2C Dom/Dom: embryonic day 12.5; Sox10Dom/Sox10Dom (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Level Pattern Image Note
TS20: pelvic ganglion Absent S2Ciii No co-expression with Sox10.
Specimen S2E +/+: embryonic day 13.5 (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS21: pelvic ganglion migratory neural crest cell Present Regionally restricted S2Ei Expression in sacral neural crest cells
Specimen S2E Dom/+: embryonic day 13.5; Sox10Dom/Sox10+ (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Cell Type Level Pattern Image Note
TS21: pelvic ganglion migratory neural crest cell Weak Regionally restricted S2Eii Signficantly fewer sacral neural crest cells than in wildtype.
Specimen S2E Dom/Dom: embryonic day 13.5; Sox10Dom/Sox10Dom (more )
Note: Double labeled: red - p75 (Ngfr); green - Sox10 (assay MGI:7434129).
Structure Level Pattern Image Note
TS21: pelvic ganglion Absent S2Eiii No co-expression with Sox10.
Specimen S3A Vagal level +/+: embryonic day 9.0 (more )
Note: Double labeled: red - p75 (Ngfr); green - BrdU.
Structure Cell Type Level Pattern Image Note
TS14: migrating neural crest migratory neural crest cell Present S3Ai
Specimen S3A Vagal level Dom/Dom: embryonic day 9.0; Sox10Dom/Sox10Dom (more )
Note: Double labeled: red - p75 (Ngfr); green - BrdU.
Structure Cell Type Level Pattern Image Note
TS14: migrating neural crest migratory neural crest cell Present S3Aii
Specimen S3C Vagal level +/+: embryonic day 9.0 (more )
Note: Double labeled: red - p75 (Ngfr); green - TUNEL.
Structure Cell Type Level Pattern Image Note
TS14: migrating neural crest migratory neural crest cell Present S3Ci
Specimen S3C Vagal level Dom/Dom: embryonic day 9.0; Sox10Dom/Sox10Dom (more )
Note: Double labeled: red - p75 (Ngfr); green - TUNEL.
Structure Cell Type Level Pattern Image Note
TS14: migrating neural crest migratory neural crest cell Present S3Cii
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory