Pdgfra RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:75868 Lu QR, et al., Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 5;109(1):75-86
Assay type:	RNA in situ
MGI Accession ID:	MGI:7432574
Gene symbol:	Pdgfra
Gene name:	platelet derived growth factor receptor, alpha polypeptide

Probe:	Pdgfra cDNA5
Probe preparation:	Antisense RNA

Results

Specimen 2A +/+ E12.5: embryonic day 12.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS20: spinal cord ventricular layer	spinal cord oligodendrocyte	Present	Regionally restricted	2A PDGFaR E12.5 +/+	Expressed in early oligodendrocytes in the ventral ventricular zone of the neural tube at the forelimb level.

Specimen 2A -/- E12.5: embryonic day 12.5; Olig2^tm1Rth/Olig2^tm1Rth (more

)

Structure	Level	Pattern	Image	Note
TS20: spinal cord	Absent		2A PDGFaR E12.5 -/-

Specimen 2A +/+ E14.5: embryonic day 14.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS22: spinal cord	spinal cord oligodendrocyte	Present		2A PDGFaR E14.5 +/+

Specimen 2A -/- E14.5: embryonic day 14.5; Olig2^tm1Rth/Olig2^tm1Rth (more

)

Structure	Level	Pattern	Image	Note
TS22: spinal cord	Absent		2A PDGFaR E14.5 -/-

Specimen 2A +/+ E18.5: embryonic day 18.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: spinal cord	spinal cord oligodendrocyte	Present		2A PDGFaR E18.5 +/+

Specimen 2A -/- E18.5: embryonic day 18.5; Olig2^tm1Rth/Olig2^tm1Rth (more

)

Structure	Level	Pattern	Image	Note
TS26: spinal cord	Absent		2A PDGFaR E18.5 -/-

Specimen 2C Olig1+/-: postnatal day 0; Olig1^tm1(cre)Rth/Olig1⁺ (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: spinal cord	spinal cord oligodendrocyte	Present		2C PDGFaR +/-	Expressed in early oligodendrocytes.

Specimen 2C Olig1-/-: postnatal day 0; Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS27: spinal cord	spinal cord oligodendrocyte	Present		2C PDGFaR -/-	Expressed in early oligodendrocytes, similar as in the control.

Specimen 3A dorsal +/+: embryonic day 18.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: forebrain	oligodendrocyte precursor cell	Present		3A-1

Specimen 3A dorsal -/-: embryonic day 18.5; Olig2^tm1Rth/Olig2^tm1Rth (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: forebrain	oligodendrocyte precursor cell	Present	Regionally restricted	3A-2	There was no expression in the dorsal region. Only a small collection of positive cells in the ventral region.

Specimen 3A ventral +/+: embryonic day 18.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: forebrain	oligodendrocyte precursor cell	Present		3A-3

Specimen 3A ventral -/-: embryonic day 18.5; Olig2^tm1Rth/Olig2^tm1Rth (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: forebrain	oligodendrocyte precursor cell	Present	Regionally restricted	3A-4	Only a small collection of positive cells in the ventral region.

Specimen 3B +/+: embryonic day 18.5 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: hindbrain	oligodendrocyte precursor cell	Present		3B-3 , 3B-1

Specimen 3B -/-: embryonic day 18.5; Olig2^tm1Rth/Olig2^tm1Rth (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS26: hindbrain	oligodendrocyte precursor cell	Present		3B-4 , 3B-2	Nearly normal numbers of positive cells compared with the wild-type.

Specimen 7A: embryonic day 12.5; Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺, Olig1^tm1(cre)Rth/Olig1⁺ (more

)
Note: Conditional mutant. Double labeled: purple - Pdgfra; blue - Cre reporter.

Structure	Cell Type	Level	Pattern	Image	Note
TS20: spinal cord lateral wall	spinal cord oligodendrocyte	Present		7A 12.5 LacZ/PDGFalphaR	Expressed in early oligodendrocytes. Colocalization with Olig1-Cre linage expression was seen.

Specimen not shown: embryonic day 12.5; Olig1^tm1(cre)Rth/Olig1^tm1(cre)Rth (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS20: spinal cord	spinal cord oligodendrocyte	Present			Expressed in early oligodendrocytes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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