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Gene Expression Data
Assay Details
Assay
Reference: J:332642 Cohen-Gulkar M, et al., The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration. PLoS Biol. 2023 Jan;21(1):e3001924
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7431192
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-Pax6 (#PRB-278P; #30130, #901301)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 1E: embryonic day 12.5; Lhx2tm1Monu/Lhx2tm1Monu (more )
Note: Double labeled: red - Pax6; green - Mitf (assay MGI:7431193).
Structure Level Pattern Image Note
TS20: pigmented retinal epithelium Present 1E inset merge , 1E , 1E inset Pax6 Normally expressed at this stage.
Specimen 1F: embryonic day 12.5; Lhx2tm1Monu/Lhx2tm1Monu, Tg(Dct-cre)1Apdn/0 (more )
Note: Conditional mutant. Double labeled: red - Pax6; green - Mitf (assay MGI:7431193).
Structure Level Pattern Image Note
TS20: pigmented retinal epithelium Weak 1F inset merge , 1F inset Pax6 , 1F Diminished levels of expression.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory