About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:235650 Mao H, et al., Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7425183
Gene symbol: Tubb3
Gene name: tubulin, beta 3 class III
Antibody: anti-Tuj1
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2H: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 2H Expression in neuronal layer.
Specimen 2J: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: neocortex Present Regionally restricted 2J Increase in thickness of neuronal layer.
Specimen 2R,2T: embryonic day 12.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Tuj1 (Tubb3); red - CC3 (Casp3 assay MGI:7425184).
Structure Level Pattern Image Note
TS20: neocortex Present 2T , 2R
Specimen 2W: embryonic day 14.5; Emx1tm1(cre)Krj/Emx1+ (more )
Structure Level Pattern Image Note
TS22: neocortex Present 2W
Specimen 2X: embryonic day 14.5; Eif4a3tm1.1Dlsi/Eif4a3+, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: neocortex Present 2X
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory