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Gene Expression Data
Assay Details
Assay
Reference: J:329537 Martinez Traverso IM, et al., LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation. Development. 2022 Sep 15;149(18):dev200860
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7408390
Gene symbol: Ctnnb1
Gene name: catenin beta 1
Results
Specimen S2F Beta-cat Control: embryonic day 9.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS15: neural ectoderm Present Regionally restricted S2F Beta-cat Control Expression on apical edge of neuroepithelium, with apical bias in control neural tube.
TS15: migrating neural crest Present S2F Beta-cat Control Expression in cells infiltrating ventricles.
Specimen S2F Beta-cat DCKO: embryonic day 9.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: neural ectoderm Present Regionally restricted S2F Beta-cat DCKO Expression in apical edge of neural tube and in cells infiltrating ventricles.
Specimen 2E Control: embryonic day 10.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 2E Control (right) , 2E Control (left) Expression on apical edge of neuroepithelium, with an apical bias in control neural tube.
Specimen 2E DCKO: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 2E DCKO (left) , 2E DCKO (right) Loss of apical bias in neuroepithelium. No expression in neuroepithelial-derived cells within neural tube. Ectopic expression in dorsal folds but not infiltrating cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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