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Gene Expression Data
Assay Details
Assay
Reference: J:329537 Martinez Traverso IM, et al., LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation. Development. 2022 Sep 15;149(18):dev200860
Assay type: RNA in situ
MGI Accession ID: MGI:7408380
Gene symbol: Tgfb1
Gene name: transforming growth factor, beta 1
Probe: Mm-Tgfb1 (407751)
Probe preparation: Antisense
Visualized with: Fluorescence
Results
Specimen S4A Tgfb1 Control: embryonic day 9.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS15: migrating neural crest Present S4A Tgfb1 Control (left) , S4A Tgfb1 Control (right)
TS15: neural ectoderm Present S4A Tgfb1 Control (left) , S4A Tgfb1 Control (right)
Specimen S4A Tgfb1 DCKO: embryonic day 9.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: migrating neural crest Strong S4A Tgfb1 DCKO (left) , S4A Tgfb1 DCKO (right) Increased expression within neuroepithelium and migrating cells compared to control neural tube.
TS15: neural ectoderm Strong S4A Tgfb1 DCKO (left) , S4A Tgfb1 DCKO (right) Increased expression within neuroepithelium and migrating cells compared to control neural tube.
Specimen 5A Control: embryonic day 10.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS17: brain Present 5A Control , 5A Control (inset upper) , 5A Control (inset lower)
TS17: migrating neural crest Present 5A Control , 5A Control (inset upper) , 5A Control (inset lower)
Specimen 5A DCKO: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Strong 5A DCKO (inset lower) , 5A DCKO , 5A DCKO (inset upper) Increased expression in basally migrating cells on ventral edge of neural fold.
TS17: migrating neural crest Strong 5A DCKO (inset lower) , 5A DCKO , 5A DCKO (inset upper) Increased expression in basally migrating cells on ventral edge of neural fold.
Specimen 8C Control: embryonic day 10.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS17: brain Present 8C Control , 8C Control (inset left) , 8C Control (inset right) Expression in neuroepithelium and neural crest cells mibrating between neural tube and non-neural ectoderm.
TS17: migrating neural crest Present 8C Control , 8C Control (inset left) , 8C Control (inset right) Expression in neuroepithelium and neural crest cells mibrating between neural tube and non-neural ectoderm.
Specimen 8C DCKO: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Strong 8C DCKO , 8C DCKO (inset left) , 8C DCKO (inset right) Increased expression in neuroepithelial and basal mitrating cells.
TS17: migrating neural crest Strong 8C DCKO , 8C DCKO (inset left) , 8C DCKO (inset right) Increased expression in neuroepithelial and basal mitrating cells.
Specimen 8C 3CKO-T: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm, Wwtr1tm1.1Eno/Wwtr1+, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Present 8C 3CKO-T (inset left) , 8C 3CKO-T , 8C 3CKO-T (inset right) Expression in neuroepithelium and migrating neural crest cells, decreased compared to DCKO embryos.
TS17: migrating neural crest Present 8C 3CKO-T (inset left) , 8C 3CKO-T , 8C 3CKO-T (inset right) Expression in neuroepithelium and migrating neural crest cells, decreased compared to DCKO embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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