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Gene Expression Data
Assay Details
Assay
Reference: J:329537 Martinez Traverso IM, et al., LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation. Development. 2022 Sep 15;149(18):dev200860
Assay type: RNA in situ
MGI Accession ID: MGI:7408373
Gene symbol: Snai2
Gene name: snail family zinc finger 2
Probe: Mm-Snai2 (451191)
Probe preparation: Antisense
Visualized with: Fluorescence
Results
Specimen S4A Snai2 Control: embryonic day 9.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS15: migrating neural crest Present S4A Snai2 Control (right) , S4A Snai2 Control (left)
TS15: neural ectoderm Present S4A Snai2 Control (right) , S4A Snai2 Control (left)
Specimen S4A Snai2 DCKO: embryonic day 9.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: neural ectoderm Strong S4A Snai DCKO (right) , S4A Snai2 DCKO (left) Expression significantly increased in neural tube compared to control.
Specimen 4C Control: embryonic day 10.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS17: brain Present 4C Control (inset) , 4C Control Expression in neuroepithelium.
TS17: migrating neural crest Present Regionally restricted 4C Control , 4C Control (inset) Expression in migrating cells between neural tube and non-neural ectoderm.
Specimen 4C DCKO: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Strong 4C DCKO (inset) , 4C DCKO Expression significantly increased in neural tube compared to control.
TS17: migrating neural crest Strong Regionally restricted 4C DCKO , 4C DCKO (inset) Highly expressed in migrating cells near dorsal folds.
Specimen 8A Control: embryonic day 10.5; Lats1tm1.1Jfm/?, Lats2tm1.1Jfm/? (more )
Structure Level Pattern Image Note
TS17: brain Present 8A Control , 8A Control (inset left) , 8A Control (inset right) Expression in neuroepithelial and migrating cells between neural tube and non-neural ectoderm.
TS17: migrating neural crest Present 8A Control , 8A Control (inset left) , 8A Control (inset right) Expression in neuroepithelial and migrating cells between neural tube and non-neural ectoderm.
Specimen 8A DCKO: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Strong 8A DCKO (inset right) , 8A DCKO , 8A DCKO (inset left) Increased expression in neuroepithelium and migrating cells.
TS17: migrating neural crest Strong 8A DCKO (inset right) , 8A DCKO , 8A DCKO (inset left) Increased expression in neuroepithelium and migrating cells.
Specimen 8A 3CKO-T: embryonic day 10.5; E2f1Tg(Wnt1-cre)2Sor/0, Lats1tm1.1Jfm/Lats1tm1.1Jfm, Lats2tm1.1Jfm/Lats2tm1.1Jfm, Wwtr1tm1.1Eno/Wwtr1+, Yap1tm1.1Eno/Yap1tm1.1Eno (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: brain Present 8A 3CKO-T (inset left) , 8A 3CKO-T , 8A 3CKO-T (inset rigth) Expression not increased in neuroepithelial and migrating cells compared to control.
TS17: migrating neural crest Present 8A 3CKO-T (inset left) , 8A 3CKO-T , 8A 3CKO-T (inset rigth) Expression not increased in neuroepithelial and migrating cells compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory