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Gene Expression Data
Assay Details
Assay
Reference: J:326033 Kim M, et al., Synovial joint cavitation initiates with microcavities in interzone and is coupled to skeletal flexion and elongation in developing mouse embryo limbs. Biol Open. 2022 Jun 15;11(6):bio059381
Assay type: RNA in situ
MGI Accession ID: MGI:7408250
Gene symbol: Gdf5
Gene name: growth differentiation factor 5
Probe: Mm-Gdf5 (407211)
Probe preparation: Antisense RNA
Results
Specimen 4 E14.5 control: embryonic day 14.5; Has2tm1.1Yama/Has2+ (more )
Structure Level Pattern Image Note
TS22: hindlimb joint Strong Regionally restricted 6A-1 Significantly expressed in, and restricted to, the interzone in the largely uncavitated knee.
Specimen 4 E14.5 cKO: embryonic day 14.5; Has2tm1.1Yama/Has2tm1.1Yama, Tg(Gdf5-cre,-ALPP)1Kng/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: hindlimb joint Strong 6A-2 Expression remained strong and seemingly unaffected in the mutants.
Specimen 4 E15.5 control: embryonic day 15.5; Has2tm1.1Yama/Has2+ (more )
Structure Level Pattern Image Note
TS23: hindlimb joint Strong Regionally restricted 6A-3 Expressed in the stereotypic interzone.
Specimen 4 E15.5 cKO: embryonic day 15.5; Has2tm1.1Yama/Has2tm1.1Yama, Tg(Gdf5-cre,-ALPP)1Kng/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: hindlimb joint Strong 6A-4 Expression remained strong and seemingly unaffected in the mutants.
Specimen 4 E16.5 control: embryonic day 16.5; Has2tm1.1Yama/Has2+ (more )
Structure Level Pattern Image Note
TS24: knee joint Strong Regionally restricted 6A-5 Expressed in the stereotypic interzone.
Specimen 4 E16.5 cKO: embryonic day 16.5; Has2tm1.1Yama/Has2tm1.1Yama, Tg(Gdf5-cre,-ALPP)1Kng/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: knee joint Present 6A-6 Expression remained strong and seemingly unaffected in the mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory