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Gene Expression Data
Assay Details
Assay
Reference: J:329966 Bell CJ, et al., Borcs6 is required for endo-lysosomal degradation during early development. Mol Reprod Dev. 2022 Aug;89(8):337-350
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7398478
Gene symbol: Borcs6
Gene name: BLOC-1 related complex subunit 6
Reporter: lacZ
Direct Detection
Assay notes: Fixation with 0.2% glutaraldehyde, 1% formaldehyde.
Results
Specimen 1a (heterozygous): embryonic day 3.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS4: inner cell mass Present Widespread 1a
TS4: trophectoderm Present Widespread 1a
Specimen 1b: embryonic day 5.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS7: extraembryonic ectoderm Strong 1b Robust expression in extraembryonic ectoderm.
TS7: primitive endoderm Present Regionally restricted 1b Robust expression in visceral endoderm. Less expression in distal half of visceral endoderm.
TS7: epiblast Weak 1b Less expression in epiblast .
Specimen 1c: embryonic day 6.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS9: extraembryonic ectoderm Strong 1c Robust expression in extraembryonic ectoderm
TS9: primitive endoderm Present Regionally restricted 1c Expression in distal half of visceral endoderm.
TS9: embryo Trace Regionally restricted 1c Further reduction of expression in epiblast.
Specimen 1d: embryonic day 7.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS11: extraembryonic ectoderm Present Widespread 1d Expression throughout extraembryonic ectoderm and visceral endoderm.
TS11: primitive endoderm Present Widespread 1d Expression throughout extraembryonic ectoderm and visceral endoderm.
Specimen 1f: embryonic day 4.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS6: epiblast Present Widespread 1f Expression in throughout embryo, both in trophectoderm and inner cell mass.
TS6: trophectoderm Present Widespread 1f Expression in throughout embryo, both in trophectoderm and inner cell mass.
Specimen 1g: embryonic day 5.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS7: extraembryonic ectoderm Strong 1g , 1g' Robust expression in extraembryoic ectoderm.
TS7: primitive endoderm Present Regionally restricted 1g , 1g'' Expression in distal half of visceral endoderm.
TS7: epiblast Weak 1g'' , 1g Expression in epiblast.
Specimen 1h: embryonic day 6.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS9: extraembryonic ectoderm Strong 1h , 1h' Robust expression in extraembryoic ectoderm.
TS9: primitive endoderm Present Regionally restricted 1h'' , 1h Expression in distal half of visceral endoderm.
TS9: embryo Trace 1h , 1h'' Expression in epiblast.
Specimen 1i: embryonic day 7.5; Borcs6tm1.1(KOMP)Vlcg/Borcs6+ (more )
Structure Level Pattern Image Note
TS11: extraembryonic ectoderm Present Widespread 1i' , 1i Expression throughout extraembryonic ectoderm.
TS11: primitive endoderm Trace Regionally restricted 1i , 1i'' Sparce expression in distal half of visceral endoderm.
TS11: embryo Trace 1i'' , 1i Sparce expression in epiblast.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory