Cdh1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:328989 Patel SD, et al., Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Front Cell Dev Biol. 2022;10:981893
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7388371
Gene symbol:	Cdh1
Gene name:	cadherin 1

Antibody:	anti-E-Cadherin (24E10; #3195)
Detection system:	Secondary antibody coupled to Alexa Fluor 568

Results

1_control row 1 ©

1_control row 2 ©

1_control row 3 ©

1_control row 4 ©

Specimen 1 Control: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: lens epithelium	Present	Uniform	1_control row 2 , 1_control row 3 , 1_control row 1 , 1_control row 4

1_KO1 row 1 ©

1_KO1 row 2 ©

1_KO1 row 3 ©

1_KO1 row 4 ©

Specimen 1 KO1: embryonic day 16.5; Mafg^tm1Jeng/Mafg^tm1Jeng, Mafk^tm1Jeng/Mafk^tm1Jeng (more

)

Structure	Level	Pattern	Image	Note
TS24: lens epithelium	Present		1_KO1 row 3 , 1_KO1 row 1 , 1_KO1 row 4 , 1_KO1 row 2	Expression in this mutant revealed cellular abnormalities and expressing cells extend further toward the posterior region.

1_KO2 row 1 ©

1_KO2 row 2 ©

1_KO2 row 3 ©

1_KO2 row 4 ©

Specimen 1 KO2: embryonic day 16.5; Mafg^tm1Jeng/Mafg^tm1Jeng, Mafk^tm1Jeng/Mafk^tm1Jeng (more

)

Structure	Level	Pattern	Image	Note
TS24: lens epithelium	Present		1_KO2 row 2 , 1_KO2 row 3 , 1_KO2 row 4 , 1_KO2 row 1	Expression in this mutant revealed cellular abnormalitiess and expressing cells extend further toward the posterior region.

2_Control row 1 ©

2_Control row 2 ©

2_Control row 3 ©

Specimen 2 Control: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: lens vesicle epithelium	Present	Uniform	2_Control row 1 , 2_Control row 2 , 2_Control row 3

2_Mafg^-/-:Mafk^-/- row 1 ©

2_Mafg^-/-:Mafk^-/- row 2 ©

2_Mafg^-/-:Mafk^-/- row 3 ©

Specimen 2 Mafg^-/-:Mafk^-/-: embryonic day 12.5; Mafg^tm1Jeng/Mafg^tm1Jeng, Mafk^tm1Jeng/Mafk^tm1Jeng (more

)

Structure	Level	Pattern	Image	Note
TS20: lens vesicle epithelium	Present		2_Mafg^-/-:Mafk^-/- row 3 , 2_Mafg^-/-:Mafk^-/- row 2 , 2_Mafg^-/-:Mafk^-/- row 1	This mutant exhibited regions of disorganization in the epithelium compared to controls and expressing cells extend further toward the posterior region.

S2_Control row 1 ©

S2_Control row 2 ©

S2_Control row 3 ©

Specimen S2 Control: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: lens epithelium	Present	Uniform	S2_Control row 1 , S2_Control row 2 , S2_Control row 3

Specimen S2 Mafg^-/-:Mafk^-/-: embryonic day 14.5; Mafg^tm1Jeng/Mafg^tm1Jeng, Mafk^tm1Jeng/Mafk^tm1Jeng (more

)

Structure	Level	Pattern	Image	Note
TS22: lens epithelium	Present		S2_Mafg^-/-:Mafk^-/- row 1 , S2_Mafg^-/-:Mafk^-/- row 3 , S2_Mafg^-/-:Mafk^-/- row 2	This mutant exhibited regions of disorganization in the epithelium compared to control.

Specimen S3 Control: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: lens epithelium	Present		S3_Control row 2 , S3_Control row 1

Specimen S3 Mafg^-/-:Mafk^-/-: embryonic day 16.5; Mafg^tm1Jeng/Mafg^tm1Jeng, Mafk^tm1Jeng/Mafk⁺ (more

)

Structure	Level	Pattern	Image	Note
TS24: lens epithelium	Present		S3_Mafg^-/-:Mafk^-/-row 1 , S3_Mafg^-/-:Mafk^-/-row 2	This mutant does not exhibit severe lens epithelial cell defects compared to the double knockout.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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