Cfl1 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:116586 Li H, et al., Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci. 2006 Oct;33(2):136-49
Assay type:	RNA in situ
MGI Accession ID:	MGI:7367161
Gene symbol:	Cfl1
Gene name:	cofilin 1, non-muscle

Probe:	Cfl1 cDNA1
Probe preparation:	Antisense labelled with S35 RNA

Results

Specimen 2A: embryonic day 15.5 (more

)

Structure	Level	Pattern	Image	Note
TS23: cerebral cortex subventricular zone	Strong	Graded	2A	Expression is is decreasing from anterior to posterior.
TS23: cerebral cortex ventricular layer	Strong	Graded	2A	Expression is is decreasing from anterior to posterior.
TS23: cortical plate	Strong	Graded	2A	Expression is is decreasing from anterior to posterior.
TS23: hippocampus	Strong		2A

Specimen 2A': embryonic day 15.5; Emx2^tm1Pgr/Emx2^tm1Pgr (more

)

Structure	Level	Pattern	Image	Note
TS23: cortical plate	Strong		2A'	Expression in this mutant in the posterior part has increased to a matching level to the anterior part.
TS23: corpus striatum	Present		2A'

Specimen 2B: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: cortical plate	Strong	Graded	2B	There is a high rostral to low caudal expression gradient.
TS26: cortical subplate	Strong	Graded	2B	There is a high rostral to low caudal expression gradient.
TS26: hippocampus	Strong		2B
TS26: cerebral cortex subventricular zone	Present		2B
TS26: cerebral cortex ventricular zone	Present		2B
TS26: corpus striatum	Present		2B
TS26: dentate gyrus	Present		2B
TS26: main olfactory bulb	Present		2B
TS26: thalamus	Present		2B

Specimen 2B': embryonic day 18.5; Emx2^tm1Pgr/Emx2^tm1Pgr (more

)

Structure	Level	Pattern	Image	Note
TS26: cortical plate	Strong	Uniform	2B'	Expression is in a nearly uniform pattern along the anterior-posterior axis.
TS26: cortical subplate	Strong	Uniform	2B'	Expression is in a nearly uniform pattern along the anterior-posterior axis.
TS26: cerebral cortex	Strong		2B'	Expression has expanded/shifted towards the caudal end.

Specimen 2C: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: cortical plate	Strong	Graded	2C	There is a high rostral to low caudal expression gradient.
TS26: cortical subplate	Strong	Graded	2C	There is a high rostral to low caudal expression gradient.
TS26: hippocampus	Strong		2C
TS26: cerebral cortex subventricular zone	Present		2C
TS26: cerebral cortex ventricular zone	Present		2C
TS26: corpus striatum	Present		2C
TS26: dentate gyrus	Present		2C
TS26: main olfactory bulb	Present		2C
TS26: thalamus	Present		2C

Specimen 2C': embryonic day 18.5; Pax6^Sey/Pax6^Sey (more

)

Structure	Level	Image	Note
TS26: cortical plate	Strong	2C'	Expression in this mutant is similar to wild-type.
TS26: cortical subplate	Strong	2C'	Expression in this mutant is similar to wild-type.
TS26: hippocampus	Strong	2C'	Expression in this mutant is similar to wild-type.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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