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Gene Expression Data
Assay Details
Assay
Reference: J:236404 Minocha S, et al., Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification. Dev Biol. 2016 Oct 1;418(1):75-88
Assay type: RNA in situ
MGI Accession ID: MGI:7356413
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Probe: pOtd9
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 9Ag: embryonic day 6.5; Hcfc1tm1Lwh/Y (more )
Structure Level Pattern Image Note
TS9: embryo ectoderm Present Graded 9Ag Anterior-posterior polarity was seen.
TS9: embryonic visceral endoderm Present 9Ag
Specimen 9Ag': embryonic day 6.5; Hcfc1tm1Lwh/Y, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS9: embryo ectoderm Present Regionally restricted 9Ag' Reduced expression at the distal epiblast.
TS9: embryonic visceral endoderm Absent 9Ag'
Specimen 9Bc: embryonic day 7.5; Hcfc1tm1Lwh/Y (more )
Structure Level Pattern Image Note
TS11: primitive streak Present 9Bc
Specimen 9Bc': embryonic day 7.5; Hcfc1tm1Lwh/Y, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS11: embryo ectoderm Present 9Bc' Reduced expression and their graded distribution which marks the anterior-posterior axis was impaired.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory