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Gene Expression Data
Assay Details
Assay
Reference: J:182446 Kon N, et al., Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem. 2012 Feb 10;287(7):5102-11
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7343922
Gene symbol: Ins1
Gene name: insulin I
Antibody: anti-insulin
Assay notes: The specificity of the antibody used was not detailed; both family members have been annotated.
Results
Specimen 3Aii: postnatal month 1; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 3Aii Expressed in the core of the islet.
Specimen 3Av: postnatal month 1; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 3Av Similar as in the control, expressed in the core of the islet.
Specimen 4Bi: postnatal month 1; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 4Bi Expressed in round shape and center-located beta-cells.
Specimen 4Bii: postnatal month 6; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 4Bii Expressed in round shape and center-located beta-cells.
Specimen 4Biii: postnatal month 9; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 4Biii Expressed in round shape and center-located beta-cells.
Specimen 4Bvii: postnatal month 1; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present 4Bvii Similar as in the control, expressed in the core of the islet.
Specimen 4Bviii: postnatal month 6; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present 4Bviii The morphology became increasingly irregular with frequent infiltration of alpha-cells in the middle of the islets.
Specimen 4Bix: postnatal month 9; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Weak 4Bix Near absence of staining, with worsened disruption of the islet structure.
Specimen 6B: postnatal month 9; Huwe1tm1Wgu/Y (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 6B Expressed in the core of the islet.
Specimen 6D: postnatal month 9; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Weak 6D Near absence of staining, with disruption of the islet structure.
Specimen 6F: postnatal month 9; Huwe1tm1Wgu/Y, Trp53tm1Thl/Trp53tm1Thl (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 6F Expressed in the core of the islet.
Specimen 6H: postnatal month 9; Huwe1tm1Wgu/Y, Tg(Ins2-cre)23Herr/0, Trp53tm1Thl/Trp53tm1Thl (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans type B pancreatic cell Present Regionally restricted 6H Similar as in the wild-type control, expressed in the core of the islet.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory