About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:216076 Hou C, et al., Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice. Dev Biol. 2014 Nov 1;395(1):167-81
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7341510
Gene symbol: Calb1
Gene name: calbindin 1
Antibody: anti-calbindin D28K
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 8Aa: postnatal day 9 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 8Aa

Specimen 8Ab: postnatal day 9; Llgl1tm1Vv/Llgl1tm1Vv, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 8Ab A clear reduction in the extent of lobule formation was seen, compared to wild-type mice. The total number was also significantly reduced.

Specimen 8Ad: postnatal day 9 (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 8Ad

Specimen 8Ae: postnatal day 9; Llgl1tm1Vv/Llgl1tm1Vv, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Purkinje cell Present 8Ae Impaired and stunted dendritic arborisation (40.3% decrease in length of the dendrites) was seen.
TS28: cerebellum white matter Weak 8Ae

Specimen 8Ba: embryonic day 14.0 (more )
Structure Cell Type Level Pattern Image Note
TS22: cerebellum layer Purkinje cell Present 8Ba

Specimen 8Bd: embryonic day 14.0; Llgl1tm1Vv/Llgl1tm1Vv, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: cerebellum layer Purkinje cell Present 8Bd Fewer and disorganised positive cells were seen.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory