Casp3 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:325976 Piprek RP, et al., Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads. Reproduction. 2022 Feb 24;163(4):199-207
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7330138
Gene symbol:	Casp3
Gene name:	caspase 3

Antibody:	anti-cleaved caspase 3 (L0104)
Assay notes:	Genetic background of control specimens was either Dsp1fl/fl or Nr5a1-Cre. Data for specimens not shown in figures presented in graph in Figure 3J.

Results

Specimen 3C: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: testis	Weak		3C

Specimen 3D: embryonic day 18.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS26: seminiferous cord	Present		3D

Specimen 3G: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: ovary	Weak		3G

Specimen 3H: embryonic day 18.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS26: ovary	Strong		3H

Specimen E10.5 XY control: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: gonad primordium	Weak

Specimen E10.5 XY KO: embryonic day 10.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS17: gonad primordium	Weak

Specimen E11.5 XY control: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: gonad	Weak

Specimen E11.5 XY KO: embryonic day 11.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: gonad	Weak

Specimen E12.5 XY control: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: testis	Weak

Specimen E12.5 XY KO: embryonic day 12.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: testis	Weak

Specimen E13.5 XY control: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: testis	Weak

Specimen E13.5 XY KO: embryonic day 13.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: testis	Weak

Specimen E14.5 XY control: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: testis	Weak

Specimen E14.5 XY KO: embryonic day 14.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: testis	Weak

Specimen E16.5 XY control: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: testis	Present

Specimen E16.5 XY KO: embryonic day 16.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS24: testis	Strong			Significant difference between control and knock out starting from E16.5

Specimen E18.5 XY control: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: testis	Present

Specimen E18.5 XY KO: embryonic day 18.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS26: testis	Strong

Specimen 1dpp XY control: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: testis	Present

Specimen 1dpp XY KO: postnatal day 1; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS27: testis	Strong

Specimen 2dpp XY control: postnatal day 2 (more

)

Structure	Level	Pattern	Image	Note
TS27: testis	Present

Specimen 2dpp XY KO: postnatal day 2; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS27: testis	Present

Specimen E10.5 XX control: embryonic day 10.5 (more

)

Structure	Level	Pattern	Image	Note
TS17: gonad primordium	Weak

Specimen E10.5 XX KO: embryonic day 10.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS17: gonad primordium	Weak

Specimen E11.5 XX control: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: gonad	Weak

Specimen E11.5 XX KO: embryonic day 11.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS19: gonad	Weak

Specimen E12.5 XX control: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: ovary	Weak

Specimen E12.5 XX KO: embryonic day 12.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: ovary	Weak			N

Specimen E13.5 XX control: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: ovary	Weak

Specimen E13.5 XX KO: embryonic day 13.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: ovary	Weak

Specimen E14.5 XX control: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: ovary	Weak

Specimen E14.5 XX KO: embryonic day 14.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: ovary	Weak

Specimen E16.5 XX control: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: ovary	Present

Specimen E16.5 XX KO: embryonic day 16.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS24: ovary	Strong			Significant difference between control and knock out starting from E16.5.

Specimen E18.5 XX control: embryonic day 18.5 (more

)

Structure	Level	Pattern	Image	Note
TS26: ovary	Present

Specimen E18.5 XX KO: embryonic day 18.5; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS26: ovary	Strong

Specimen 1dpp XX control: postnatal day 1 (more

)

Structure	Level	Pattern	Image	Note
TS27: ovary	Present

Specimen 1dpp XX KO: postnatal day 1; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS27: ovary	Strong

Specimen 2dpp XX control: postnatal day 2 (more

)

Structure	Level	Pattern	Image	Note
TS27: ovary	Present

Specimen 2dpp XX KO: postnatal day 2; Dsp^tm1Efu/Dsp^tm1Efu, Tg(Nr5a1-cre)7Lowl/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS27: ovary	Strong

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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