Pdpn Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:325049 Xu W, et al., Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Int J Mol Sci. 2022 May 20;23(10)
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:7327639
Gene symbol:	Pdpn
Gene name:	podoplanin

Antibody:

Results

4B Gprc5b+/+ ©

Specimen 4B Gprc5b+/+: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: back skin	Present	Regionally restricted	4B Gprc5b+/+	Branching network of dermal lymphatic vasculature.
TS22: lymphatic vessel	Present	Regionally restricted	4B Gprc5b+/+	Branching network of dermal lymphatic vasculature.

4B Gprc5b-/- ©

Specimen 4B Gprc5b-/-: embryonic day 14.5; Gprc5b^{tm1b(EUCOMM)Wtsi}/Gprc5b^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS22: back skin	Present	Regionally restricted	4B Gprc5b-/-	Network of lymphatic vasculature markedly attenuated compared with controls.
TS22: lymphatic vessel	Present	Regionally restricted	4B Gprc5b-/-	Network of lymphatic vasculature markedly attenuated compared with controls.

4D Gprc5b+/+ ©

Specimen 4D Gprc5b+/+: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: back skin	Present	Regionally restricted	4D Gprc5b+/+	Close proximity of lymphoangiogenic fronts near the dorsal midline.
TS22: lymphatic vessel	Present	Regionally restricted	4D Gprc5b+/+	Close proximity of lymphoangiogenic fronts near the dorsal midline.

4D Gprc5b-/- ©

Specimen 4D Gprc5b-/-: embryonic day 14.5; Gprc5b^{tm1b(EUCOMM)Wtsi}/Gprc5b^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS22: back skin	Present	Regionally restricted	4D Gprc5b-/-	Growth and migration of dorsal lymphatics toward midline severely blunted.
TS22: lymphatic vessel	Present	Regionally restricted	4D Gprc5b-/-	Growth and migration of dorsal lymphatics toward midline severely blunted.

Specimen 6A Gprc5b+/+: postnatal day 7 (more

)

Structure	Level	Pattern	Image	Note
TS28: heart	Present	Regionally restricted	6A Gprc5b+/+ (left) , 6A Gprc5b+/+ (right)	Cardiac lymphatics expand to cover surface of myocardium between postnatal days 1 and 15.
TS28: lymphatic vessel	Present	Regionally restricted	6A Gprc5b+/+ (left) , 6A Gprc5b+/+ (right)	Cardiac lymphatics expand to cover surface of myocardium between postnatal days 1 and 15.

Specimen 6A Gprc5b-/-: postnatal day 7; Gprc5b^{tm1b(EUCOMM)Wtsi}/Gprc5b^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: heart	Present	Regionally restricted	6A Gprc5b-/- (right) , 6A Gprc5b-/- (left)	Cardiac lymphatic growth and surface area coverage significantly attenuated compared with controls.
TS28: lymphatic vessel	Present	Regionally restricted	6A Gprc5b-/- (right) , 6A Gprc5b-/- (left)	Cardiac lymphatic growth and surface area coverage significantly attenuated compared with controls.

Specimen 6D Gprc5b+/+: postnatal day 21 (more

)

Structure	Level	Pattern	Image	Note
TS28: heart	Present	Regionally restricted	6D Gprc5b+/+ (right) , 6D Gprc5b+/+ (left)	Authors report normal and robust cardiac lympangiogenesis.
TS28: lymphatic vessel	Present	Regionally restricted	6D Gprc5b+/+ (right) , 6D Gprc5b+/+ (left)	Authors report normal and robust cardiac lympangiogenesis.

Specimen 6D Gprc5b-/-: postnatal day 21; Gprc5b^{tm1b(EUCOMM)Wtsi}/Gprc5b^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: heart	Present	Regionally restricted	6D Gprc5b-/- (right) , 6D Gprc5b-/- (left)	Authors report normal and robust cardiac lympangiogenesis in mice that did not suffer from growth restriction.
TS28: lymphatic vessel	Present	Regionally restricted	6D Gprc5b-/- (right) , 6D Gprc5b-/- (left)	Authors report normal and robust cardiac lympangiogenesis in mice that did not suffer from growth restriction.

Specimen 6D Gprc5b-/- Growth Restricted: postnatal day 21; Gprc5b^{tm1b(EUCOMM)Wtsi}/Gprc5b^{tm1b(EUCOMM)Wtsi} (more

)

Structure	Level	Pattern	Image	Note
TS28: heart	Present	Regionally restricted	6D Gprc5b-/- Growth Restricted (right) , 6D Gprc5b-/- Growth Restricted (left)	Cardiac lympangiogenesis persistently attenuated in growth-restricted animals.
TS28: lymphatic vessel	Present	Regionally restricted	6D Gprc5b-/- Growth Restricted (right) , 6D Gprc5b-/- Growth Restricted (left)	Cardiac lympangiogenesis persistently attenuated in growth-restricted animals.

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