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Gene Expression Data
Assay Details
Assay
Reference: J:148693 Narimatsu M, et al., Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009 Apr 17;137(2):295-307
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7327067
Gene symbol: Prickle1
Gene name: prickle planar cell polarity protein 1
Results
Specimen 6A WT: embryonic day 18.5 (more )
Note: Double labeled: white - Prickle1; red - phalloidin.
Structure Level Pattern Image Note
TS26: cochlea Present Regionally restricted 6A WT Strong colocalization with F-actin in crescent on medial aspect, extending apically into cuticular plate.
Specimen 6A Smurf1+/-;Smurf2-/-: embryonic day 18.5; Smurf1tm1Wran/Smurf1+, Smurf2tm1Wran/Smurf2tm1Wran (more )
Note: Double labeled: white - Prickle1; red - phalloidin.
Structure Level Pattern Image Note
TS26: cochlea Present Regionally restricted 6A Smurf1+/-;Smurf2-/- Expansion of expression to lateral surfaces.
Specimen 6B i/ii WT: embryonic day 18.5 (more )
Note: Double labeled: white - Prickle1; red - phalloidin.
Structure Level Pattern Image Note
TS26: cochlea Present Regionally restricted 6Bi WT (right) , 6Bii WT , 6Bi WT (left) No expression at lateral membrane of sensory hair cells.
Specimen 6B i/ii Smurf1+/-;Smurf2-/-: embryonic day 18.5; Smurf1tm1Wran/Smurf1+, Smurf2tm1Wran/Smurf2tm1Wran (more )
Note: Double labeled: white - Prickle1; red - phalloidin.
Structure Level Pattern Image Note
TS26: cochlea Present Regionally restricted 6Bii Smurf1+/-;Smurf2-/- , 6Bi Smurf1+/-;Smurf2-/- (right) , 6Bi Smurf1+/-;Smurf2-/- (left) Accumulation at lateral membrane of sensory hair cells. Expression around entire circumference pf cortical actin.
Specimen 7A Control: embryonic day 8.0 (more )
Note: Double labeled: red - Prickle1; green - Ctnnb1 (assay MGI:7327065).
Structure Level Pattern Image Note
TS12: neural tube floor plate Present Regionally restricted 7A Control (left) , 7A Control (right) Expression in membraine of neuroectoderm cells.
Specimen 7A Smurf1-/-;Smurf2-/-: embryonic day 8.0; Smurf1tm1Wran/Smurf1tm1Wran, Smurf2tm1Wran/Smurf2tm1Wran (more )
Note: Double labeled: red - Prickle1; green - Ctnnb1 (assay MGI:7327065).
Structure Level Pattern Image Note
TS12: neural tube floor plate Present Regionally restricted 7A Smurf1-/-;Smurf2-/- (left) , 7A Smurf1-/-;Smurf2-/- (right) Expression asymmetrically distributed in individual neuroectoderm cells.
Specimen S9 top (upper): embryonic day 8.0 (more )
Note: Double labeled: red - Prickle1; green - Ctnnb1 (assay MGI:7327065).
Structure Level Pattern Image Note
TS12: neural tube floor plate Present S9_top anti-Prickle1 (upper) , S9_top Merged (upper) , S9_top Merged (enlarged) Specific expression in neurectoderm cells.
Specimen S9 top (lower): embryonic day 8.0 (more )
Note: Double labeled: red - Prickle1; green - Ctnnb1 (assay MGI:7327065).
Structure Level Pattern Image Note
TS12: neural tube floor plate Present S9_top Merged (lower) , S9_top anti-Prickle1 (lower) Specific expression in neurectoderm cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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