About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:313926 Cichon MA, et al., Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and Lymphoid Organs. Front Cell Dev Biol. 2020;8:608876
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7294409
Gene symbol: Rtn1
Gene name: reticulon 1
Results
Specimen 1B mouse: postnatal adult (more )
Structure Level Pattern Image Note
TS28: epidermis Strong Regionally restricted 1B mouse Strong expression restricted to epidermal dendritically shaped cells.
TS28: dermis Absent 1B mouse
Specimen 1D skin section MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS28: epidermis Langerhans cell Present 1D skin section MHCII Expression in Langerhans cells in epidermis, co-expressed with MHCII.
TS28: dermis dendritic cell Absent 1D skin section MHCII No expression in MHCII+ dendritic cells in dermis.
Specimen 1D epidermal sheets MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 1D epidermal sheets MHCII Co-expression with MHCII.
Specimen 1C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 1D CD207 Co-expression with CD207.
Specimen 1C CD3: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd3g (assay MGI:7294412).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 1D CD3 Expression not co-localized with CD3.
Specimen 2A E16.5: embryonic day 16.5 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS24: skin Present Single cells 2A E16.5 , 2A E16.5 inset Authors report co-expression with CD45 in a few round to polygonal cells
Specimen 2A E18.5: embryonic day 18.5 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS26: skin Present Regionally restricted 2A E18.5 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd1: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS27: epidermis Present Regionally restricted 2A pd1 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd1 inset: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; blue - Cd3g (assay MGI:7294412).
Structure Level Pattern Image Note
TS27: epidermis Present Regionally restricted 2A pd1 inset Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd3: postnatal day 3 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS27: epidermis Present Regionally restricted 2A pd3 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2A pd7: postnatal day 7 (more )
Note: Double labeled: green - Rtn1; red - Ptprc (assay MGI:7294413).
Structure Level Pattern Image Note
TS28: epidermis Present Regionally restricted 2A pd7 Expression in large population of polygonal dendritic CD45+ cells (Langerhans cell precursors). No expression in small population of round CD45+ cells.
Specimen 2B pd1: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; red - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS27: epidermis Langerhans cell Weak 2B pd1 Continuum of low to high expression in Langerhans cells during postnatal period.
Specimen 2B pd3: postnatal day 3 (more )
Note: Double labeled: green - Rtn1; red - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS27: epidermis Langerhans cell Present 2B pd3 Continuum of low to high expression in Langerhans cells during postnatal period.
Specimen 2B pd7: postnatal day 7 (more )
Note: Double labeled: green - Rtn1; red - H2-M2 (assay MGI:7294410).
Structure Cell Type Level Pattern Image Note
TS28: epidermis Langerhans cell Strong 2B pd7 Continuum of low to high expression in Langerhans cells during postnatal period.
Specimen 2D E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: skin Present Regionally restricted 2D E16.5 Expression reminiscent of nerve structures.
Specimen 2D E18.5: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: dermis Present Regionally restricted 2D dermal sheets E18.5 Expression reminiscent of nerve structures.
Specimen 2D pd1: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: dermis Absent 2D dermal sheets pd1
Specimen 2E E16.5: embryonic day 16.5 (more )
Note: Double labeled: green - Rtn1; red - Nefm (assay MGI:7294414).
Structure Level Pattern Image Note
TS24: skin Present Regionally restricted 2E E16.5 Authors report co-localization with neurofilament expression.
Specimen 2E E18.5: embryonic day 18.5 (more )
Note: Double labeled: green - Rtn1; red - Nefm (assay MGI:7294414).
Structure Level Pattern Image Note
TS26: dermis Present Regionally restricted 2E E18.5 Authors report co-localization with neurofilament expression.
Specimen 2E pd1: postnatal day 1 (more )
Note: Double labeled: green - Rtn1; red - Nefm (assay MGI:7294414).
Structure Level Pattern Image Note
TS27: dermis Absent 2E pd1
Specimen 3C MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C MHCII inset (lower) , 3C MHCII , 3C MHCII inset (upper) Expression co-localized with MHCII in some, but not all, cells.
Specimen 3C CD11c: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Itgax (assay MGI:7294415).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C CD11c inset (lower) , 3C CD11c inset (upper) , 3C CD11c Expression co-localized with CD11c in some, but not all, cells.
Specimen 3C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C CD207 , 3C CD207 inset (upper) , 3C CD207 inset (lower) There was no coexpression with CD207.
Specimen 3C F4/80: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Adgre1 (assay MGI:7294416).
Structure Level Pattern Image Note
TS28: thymus Present Regionally restricted 3C F4/80 inset (lower) , 3C F4/80 inset (upper) , 3C F4/80 Co-expression with F4/80 only in a few cells.
Specimen 4C MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C MHCII inset , 4C MHCII Expression co-localized with MHCII.
Specimen 4C CD11c: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Itgax (assay MGI:7294415).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C Cd11c , 4C Cd11c inset (lower) , 4C Cd11c inset (upper) Expression colocalized with CD11c.
Specimen 4C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C CD207 inset (upper) , 4C CD207 inset (lower) , 4C CD207 Expression colocalized with CD207.
Specimen 4C F4/80: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Adgre1 (assay MGI:7294416).
Structure Level Pattern Image Note
TS28: lymph node Present Regionally restricted 4C F4/80 inset (lower) , 4C F4/80 , 4C F4/80 inset (upper) Expression in majority of F4/80+ cells.
Specimen 5C MHCII: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - H2-M2 (assay MGI:7294410).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C MHCII , 5C MHCII inset (upper) , 5C MHCII inset (lower) Authors report co-expression with MHCII in a minute population of cells.
Specimen 5C CD11c: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Itgax (assay MGI:7294415).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C CD11c inset (lower) , 5C CD11c , 5C CD11c inset (upper) Authors report co-expression with CD11c in a minute population of cells.
Specimen 5C CD207: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Cd207 (assay MGI:7294411).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C CD207 inset (lower) , 5C CD207 inset (upper) , 5C CD207 Co-expression with CD207 in several cells localized mainly in white pulp.
Specimen 5C F4//80: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Adgre1 (assay MGI:7294416).
Structure Level Pattern Image Note
TS28: spleen Present Regionally restricted 5C F4/80 inset (lower) , 5C F4/80 , 5C F4/80 inset (upper) RTN1A , 5C F4/80 inset (upper) , 5C F4/80 inset (upper) F4/80 Expression co-localized with F4/80 in some cells
Specimen S3A: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: cerebellum Purkinje cell Present S3A
Specimen S3C B220 thymus: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Ptprc (assay MGI:7294413).
Structure Cell Type Level Pattern Image Note
TS28: thymus B cell Absent S3C B220 thymus
Specimen S3C B220 lymph node: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Ptprc (assay MGI:7294413).
Structure Cell Type Level Pattern Image Note
TS28: lymph node B cell Absent S3C B220 lymph node
Specimen S3C B220 spleen: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Ptprc (assay MGI:7294413).
Structure Cell Type Level Pattern Image Note
TS28: spleen B cell Absent S3C B220 spleen
Specimen S3C CD23 thymus: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Fcer2a (assay MGI:7294417).
Structure Cell Type Level Pattern Image Note
TS28: thymus B cell Absent S3C CD23 thymus
Specimen S3C CD23 lymph node: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Fcer2a (assay MGI:7294417).
Structure Cell Type Level Pattern Image Note
TS28: lymph node B cell Absent S3C CD23 lymph node
Specimen S3C CD23 spleen: postnatal adult (more )
Note: Double labeled: red - Rtn1; green - Fcer2a (assay MGI:7294417).
Structure Cell Type Level Pattern Image Note
TS28: spleen B cell Absent S3C CD23 spleen
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory