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Gene Expression Data
Assay Details
Assay
Reference: J:171508 Ikegami D, et al., Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
Assay type: RNA in situ
MGI Accession ID: MGI:7286339
Gene symbol: Runx2
Gene name: runt related transcription factor 2
Probe: Runx2 probe19
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 1D Sox9flox/+: embryonic day 14.5; Sox9tm2Crm/Sox9+ (more )
Note: Proximal humerus.
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Present Regionally restricted 1D Runx2 Sox9flox/+ Expression was detected in the bone collar.
Specimen 1D 11Enh-Cre; Sox9flox/flox: embryonic day 14.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)1Ntsu/0 (more )
Note: Conditional mutant. Proximal humerus.
Structure Level Pattern Image Note
TS22: humerus cartilage condensation Present Regionally restricted 1D Runx2 11Enh-Cre; Sox9flox/flox Expression was maintained in the bone collar.
Specimen 3A Sox9flox/+: embryonic day 13.5; Sox9tm2Crm/Sox9+ (more )
Note: Proximal humerus.
Structure Cell Type Level Pattern Image Note
TS21: humerus cartilage condensation Strong Regionally restricted 3A Runx2 Sox9flox/+ Strong expression was detected in bone collars of primordial cartilage.
TS21: humerus cartilage condensation chondrocyte Weak 3A Runx2 Sox9flox/+
Specimen 3A 11Prom-Cre; Sox9flox/flox: embryonic day 13.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)2Ntsu/0 (more )
Note: Conditional mutant. Proximal humerus.
Structure Cell Type Level Pattern Image Note
TS21: humerus cartilage condensation chondrocyte Present 3A Runx2 11Prom-Cre; Sox9flox/flox Expression was increased in the conditional mutant chondrocytes.
Specimen S2C Sox9flox/wt: embryonic day 15.5; Sox9tm2Crm/Sox9+ (more )
Note: Proximal humerus.
Structure Level Pattern Image Note
TS23: humerus Ambiguous S2C Runx2 Sox9flox/+
Specimen S2C 11Enh-Cre; Sox9flox/flox: embryonic day 15.5; Sox9tm2Crm/Sox9tm2Crm, Tg(Col11a2-cre)1Ntsu/0 (more )
Note: Conditional mutant. Proximal humerus.
Structure Level Pattern Image Note
TS23: humerus Ambiguous S2C Runx2 11Enh-Cre;Sox9flox/flox
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory