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Gene Expression Data
Assay Details
Assay
Reference: J:304565 Bi-Lin KW, et al., Critical role of the BAF chromatin remodeling complex during murine neural crest development. PLoS Genet. 2021 Mar;17(3):e1009446
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7282114
Gene symbol: Tagln
Gene name: transgelin
Results
Specimen 3Q: embryonic day 11.5; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Double labeled: green - Tagln; red - R26mTmG reporter. The genetic background of the conditional control specimen was not specified, but included the R26mTmG reporter.
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 3Q Smooth muscle cells covered most of the vascular walls on the control embryo.
Specimen 3R: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1+, Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy, E2f1Tg(Wnt1-cre)2Sor/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Double labeled: green - Tagln; red - R26mTmG reporter.
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 3R No significant difference was seen in BAF170-deficient embryos compared with control.
Specimen 3S: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1tm2.1Rhs, Smarcc2tm1.1Stoy/Smarcc2+, E2f1Tg(Wnt1-cre)2Sor/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Double labeled: green - Tagln; red - R26mTmG reporter.
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted 3S In the BAF155-deficient embryos, immunopositive cells were observed but not properly distributed throughout the vascular wall.
Specimen 3T: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1tm2.1Rhs, Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy, E2f1Tg(Wnt1-cre)2Sor/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Double labeled: green - Tagln; red - R26mTmG reporter.
Structure Level Pattern Image Note
TS19: 4th arch artery Weak Regionally restricted 3T Immunopositive cells were nearly absent from the vascular walls of the BAF155-170-deficient embryos.
Specimen 4I: embryonic day 11.5; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: The genetic background of the conditional control specimen was not specified, but included the R26mTmG reporter.
Structure Level Pattern Image Note
TS19: outflow tract Present Regionally restricted 4I Expression was detected in cells surrounding the outflow tract.
TS19: endocardial cushion Present Regionally restricted 4I Expression was detected in the conotruncal cushions.
Specimen 4J: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1tm2.1Rhs, Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy, E2f1Tg(Wnt1-cre)2Sor/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: outflow tract Present Regionally restricted 4J Expression was detected in the mutant outflow tract.
TS19: endocardial cushion Weak Regionally restricted 4J The number of immunopositive cells was considerably decreased in the mutant compared to the controls.
Specimen 4K: embryonic day 11.5; Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Double labeled: red - Tagln; green - R26mTmG reporter. The genetic background of the conditional control specimen was not specified, but included the R26mTmG reporter.
Structure Level Pattern Image Note
TS19: endocardial cushion Present Regionally restricted 4K Expression was detected in the conotruncal cushions.
Specimen 4L: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1tm2.1Rhs, Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy, E2f1Tg(Wnt1-cre)2Sor/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant. Double labeled: red - Tagln; green - R26mTmG reporter.
Structure Level Pattern Image Note
TS19: endocardial cushion Weak Regionally restricted 4L The decreased number of immunopositive cells in the conotruncal cushions of the mutant was due to a reduced number of migrating GFP+ neural crest cells.
Specimen S2A: embryonic day 11.5 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted S2A Smooth muscle cells covered most of the vascular walls on the control embryo.
Specimen S2B: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1+, Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy, Pax3tm1(cre)Joe/Pax3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted S2B
Specimen S2C: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1tm2.1Rhs, Smarcc2tm1.1Stoy/Smarcc2+, Pax3tm1(cre)Joe/Pax3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: 4th arch artery Present Regionally restricted S2C
Specimen S2D: embryonic day 11.5; Smarcc1tm2.1Rhs/Smarcc1tm2.1Rhs, Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy, Pax3tm1(cre)Joe/Pax3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: 4th arch artery Weak Regionally restricted S2D Pax3-Cre;BAF155;BAF170 deficient embryos showed a severe deficiency of immunopositive cells in the vascular wall of the pharyngeal arch artery.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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