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Gene Expression Data
Assay Details
Assay
Reference: J:311933 Kong JH, et al., Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development. 2021 Oct 1;148(19):dev199867
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7279114
Gene symbol: Smo
Gene name: smoothened, frizzled class receptor
Antibody: anti-Smo
Results
Specimen 2E Spinal cord Control: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: future spinal cord Ambiguous 2E e8.5 Control (right)
Specimen 2E Spinal cord Mosmo-/-: embryonic day 8.5; Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS13: future spinal cord Strong 2E e8.5 Mosmo-/- (right) Authors report constitutive high-level expression in priimary cilia.
Specimen 2E Heart Control: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: heart Ambiguous 2E Heart Control (right)
Specimen 2E Heart Mosmo-/-: embryonic day 12.5; Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS20: heart Strong Regionally restricted 2E Heart Mosmo-/- (right) Authors report constitutive high-level expression in priimary cilia.
Specimen 2E Limb Control: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: limb Ambiguous 2E Limb Control (right)
Specimen 2E Limb Mosmo-/-: embryonic day 12.5; Mosmoem1Rroh/Mosmoem1Rroh (more )
Structure Level Pattern Image Note
TS20: limb Strong Regionally restricted 2E Limb Mosmo-/- (right) Authors report constitutive high-level expression in priimary cilia.
Specimen S6C SMO Control: embryonic day 10.5 (more )
Note: Triple labeled: red - Smo; green - Arl13b (assay MGI:7279115); blue - Sox2 (assay MGI:7279116).
Structure Level Pattern Image Note
TS17: future spinal cord Ambiguous S6C Control (merge left) , S6C Control SMO (left)
Specimen S6C SMO Control Dorsal: embryonic day 10.5 (more )
Note: Double labeled: red - Smo; green - Arl13b (assay MGI:7279115).
Structure Level Pattern Image Note
TS17: future spinal cord Ambiguous S6C Control (merge) Dorsal , S6C Control SMO Dorsal
Specimen S6C SMO Control Ventral: embryonic day 10.5 (more )
Note: Double labeled: red - Smo; green - Arl13b (assay MGI:7279115).
Structure Level Pattern Image Note
TS17: future spinal cord Ambiguous S6C Control (merge) Ventral , S6C Control SMO Ventral
Specimen S6C SMO Mosmo-/-: embryonic day 10.5; Mosmoem1Rroh/Mosmoem1Rroh (more )
Note: Triple labeled: red - Smo; green - Arl13b (assay MGI:7279115); blue - Sox2 (assay MGI:7279116).
Structure Level Pattern Image Note
TS17: future spinal cord Present Widespread S6C Mosmo-/- (merge left) , S6C Mosmo-/- SMO (left) Markedly elevated expression along entire-dorsal ventral axis of spinal cord.
Specimen S6C SMO Mosmo-/- Dorsal: embryonic day 10.5; Mosmoem1Rroh/Mosmoem1Rroh (more )
Note: Double labeled: red - Smo; green - Arl13b (assay MGI:7279115).
Structure Level Pattern Image Note
TS17: future spinal cord Present Widespread S6C Mosmo-/- (merge) Dorsal , S6C Mosmo-/- SMO Dorsal Markedly elevated expression along entire-dorsal ventral axis of spinal cord.
Specimen S6C SMO Mosmo-/- Ventral: embryonic day 10.5; Mosmoem1Rroh/Mosmoem1Rroh (more )
Note: Double labeled: red - Smo; green - Arl13b (assay MGI:7279115).
Structure Level Pattern Image Note
TS17: future spinal cord Present Widespread S6C Mosmo-/- SMO Ventral , S6C Mosmo-/- (merge) Ventral Markedly elevated expression along entire-dorsal ventral axis of spinal cord.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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