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Gene Expression Data
Assay Details
Assay
Reference: J:168038 Bimonte S, et al., Ofd1 is required in limb bud patterning and endochondral bone development. Dev Biol. 2011 Jan 15;349(2):179-91
Assay type: RNA in situ
MGI Accession ID: MGI:7258473
Gene symbol: Hand2
Gene name: heart and neural crest derivatives expressed 2
Probe: Hand2 probe15
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen E10.5 WT not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forelimb bud Present
Specimen E10.5 fl/+Prx1Cre not shown: embryonic day 10.5; Ofd1tm2.1Bfra/Ofd1+, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: forelimb bud Present Expression normal compared to wildtype
Specimen E10.5 fl/yPrx1Cre not shown: embryonic day 10.5; Ofd1tm2.1Bfra/Y, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: forelimb bud Present Expression normal compared to wildtype.
Specimen S6G: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted S6G Expression confined to posterior region of limb bud.
Specimen S6H: embryonic day 11.5; Ofd1tm2.1Bfra/Ofd1+, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted S6H Expression extends anteriorly compared with wild type, with ectopic patches of expression in anterior half of limb.
Specimen S6I: embryonic day 11.5; Ofd1tm2.1Bfra/Y, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: forelimb bud Present Regionally restricted S6I Expression expanded into anterior part of limb bud. Homogeneous ectopic anterior expression.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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