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Gene Expression Data
Assay Details
Assay
Reference: J:248919 Yu W, et al., Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation. Dev Biol. 2017 Sep 1;429(1):44-55
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7258175
Gene symbol: Irx1
Gene name: Iroquois homeobox 1
Antibody: anti-Irx1 (HPA043160)
Assay notes: Two antibodies were described, but the one used in this assay was not detailed. Anti-Irx1 MGI:7258132 may have been used in this assay.
Results
Specimen 3B Irx1+/+: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor epithelium Present 3B Irx1+/+ Expression narrowed to dental epithelium.
Specimen 3B Irx1-/-: embryonic day 13.5; Irx1tm1(KOMP)Vlcg/Irx1tm1(KOMP)Vlcg (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor Absent 3B Irx1-/- Expression ablated in knockout mice.
Specimen 3D Irx1+/+ Incisor (upper): embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lower jaw incisor Present Regionally restricted 3D Irx1+/+ Incisor upper) In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
TS26: outer enamel epithelium Present Regionally restricted 3D Irx1+/+ Incisor upper) In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
TS26: stellate reticulum Present Regionally restricted 3D Irx1+/+ Incisor upper) In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
Specimen 3D Irx1+/+ Incisor (lower): embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lower jaw incisor Present Regionally restricted 3D Irx1+/+ Incisor (lower) In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
TS26: outer enamel epithelium Present Regionally restricted 3D Irx1+/+ Incisor (lower) In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
TS26: stellate reticulum Present Regionally restricted 3D Irx1+/+ Incisor (lower) In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
TS26: stratum intermedium Present Regionally restricted 3D Irx1+/+ Incisor (lower) In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
Specimen 3D Irx1+/+ Molar: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lower jaw molar Present Regionally restricted 3D Irx1+/+ Molar In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
TS26: outer enamel epithelium Present Regionally restricted 3D Irx1+/+ Molar In late bell stage teeth, expression limited to outer enamel epithelium, stratum intermedium and stellate reticulum.
Specimen 3D Irx1-/- Incisor (upper): embryonic day 18.5; Irx1tm1(KOMP)Vlcg/Irx1tm1(KOMP)Vlcg (more )
Structure Level Pattern Image Note
TS26: lower jaw incisor Absent 3D Irx1-/- Incisor (upper) Expression ablated in knockout mice.
Specimen 3D Irx1-/- Incisor (lower): embryonic day 18.5; Irx1tm1(KOMP)Vlcg/Irx1tm1(KOMP)Vlcg (more )
Structure Level Pattern Image Note
TS26: lower jaw incisor Absent 3D Irx1-/- Incisor (lower) Expression ablated in knockout mice.
Specimen 3D Irx1-/- Molar: embryonic day 18.5; Irx1tm1(KOMP)Vlcg/Irx1tm1(KOMP)Vlcg (more )
Structure Level Pattern Image Note
TS26: lower jaw molar Absent 3D Irx1-/- Molar Expression ablated in knockout mice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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