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Gene Expression Data
Assay Details
Assay
Reference: J:273624 Bourgeois JR, et al., Loss of the neurodevelopmental Joubert syndrome causing protein, Ahi1, causes motor and muscle development delays independent of central nervous system involvement. Dev Biol. 2019 Apr 1;448(1):36-47
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7255024
Gene symbol: Myh2
Gene name: myosin, heavy polypeptide 2, skeletal muscle, adult
Results
Specimen 7A: postnatal day 21 (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: soleus type II muscle cell Present 7A
Specimen 7B: postnatal day 21 (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: vastus intermedius type II muscle cell Present 7B
Specimen 7C: postnatal day 21; Ahi1tm1Rujf/Ahi1tm1Rujf (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: soleus type II muscle cell Present 7C Reduced cross sectional area (CSA) of Type II muscle fibers compared to +/+ mice.
Specimen 7D: postnatal day 21; Ahi1tm1Rujf/Ahi1tm1Rujf (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: vastus intermedius type II muscle cell Present 7D Reduced cross sectional area (CSA) of Type II muscle fibers compared to +/+ mice.
Specimen 8A: postnatal day 21 (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: soleus type II muscle cell Present 8A
Specimen 8B: postnatal day 21 (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: vastus intermedius type II muscle cell Present 8B
Specimen 8C: postnatal day 21; Ahi1tm1Rujf/Ahi1tm1Rujf (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: soleus type II muscle cell Present 8C Significant reduction of cross sectional area (CSA) of Type II muscle fibers compared to +/+ mice, to a lesser extent than seen at 3 weeks.
Specimen 8D: postnatal day 21; Ahi1tm1Rujf/Ahi1tm1Rujf (more )
Note: Triple labeled: green - Myh2; red - Myh7 (assay MGI:7255023); blue - Hoechst.
Structure Cell Type Level Pattern Image Note
TS28: vastus intermedius type II muscle cell Present 8D No reduction in cross sectional area (CSA) of Type II muscle fibers compared to +/+ mice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory