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Gene Expression Data
Assay Details
Assay
Reference: J:158688 Seshadri S, et al., Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5622-7
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6860643
Gene symbol: Disc1
Gene name: disrupted in schizophrenia 1
Antibody: anti-mExon3
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 3B NRG1-/- left: embryonic day 10.0; Nrg1tm1Cbm/Nrg1tm1Cbm (more )
Note: Double labeled: red - Disc1; green - Tubb3 (assay MGI:6861778).
Structure Level Pattern Image Note
TS16: telencephalon Weak 3B NRG1-/- Merge left , 3B NRG1-/- DISC1 left

Specimen 3B WT left: embryonic day 10.0 (more )
Note: Double labeled: red - Disc1; green - Tubb3 (assay MGI:6861778).
Structure Level Pattern Image Note
TS16: telencephalon Present 3B WT left , 3B WT Merge left

Specimen 3B NRG1-/- right: embryonic day 10.0; Nrg1tm1Cbm/Nrg1tm1Cbm (more )
Note: Double labeled: red - Disc1; green - Nes (assay MGI:6861784).
Structure Level Pattern Image Note
TS16: telencephalon Weak 3B NRG1-/- Merge right , 3B NRG1-/- DISC1 right

Specimen 3B WT right: embryonic day 10.0; Nrg1tm1Cbm/Nrg1tm1Cbm (more )
Note: Double labeled: red - Disc1; green - Nes (assay MGI:6861784).
Structure Level Pattern Image Note
TS16: telencephalon Present 3B WT right , 3B WT Merge right

Specimen S4D BACE1-/-: postnatal day 0; Bace1tm1Pcw/Bace1tm1Pcw (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Weak S4D BASE1-/- bottom , S4D BASE1-/- top , S4D BASE1-/- Merge bottom , S4D BASE1-/- Merge top Expression in cell bodies and nuclei is similar to wild-type but there is a reduction in expression in neurites in this mutant compared to wild-type.

Specimen S4D WT: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present S4D WT top , S4D WT Merge top , S4D WT bottom , S4D WT Merge bottom

Specimen S5: postnatal adult (more )
Note: Double labeled: red - Disc1; green - Gfap (assay MGI:6861797).
Structure Level Pattern Image Note
TS28: brain Present Regionally restricted S5_DISC1 , S5_Merge Expression is in astrocytes.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory