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Gene Expression Data
Assay Details
Assay
Reference: J:133832 Festoff BW, et al., Motor neuron cell death in wobbler mutant mice follows overexpression of the G-protein-coupled, protease-activated receptor for thrombin. Mol Med. 2000 May;6(5):410-29
Assay type: RNA in situ
MGI Accession ID: MGI:6850700
Gene symbol: F2r
Gene name: coagulation factor II thrombin receptor
Probe: PAR-1 probe1
Probe preparation: labelled with biotin DNA
Visualized with: Horseradish peroxidase
Results
Specimen 6A: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: spinal cord cervical region Present Uniform 6A
Specimen 6B: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: spinal cord cervical region Present 6B Expression was in neurons. Non-neuronal cells were not significantly labeled.
Specimen 6C: postnatal day 21; Vps54wr/Vps54wr (more )
Structure Level Pattern Image Note
TS28: spinal cord cervical region Strong Non-Uniform 6C In contrast to wild type, the pattern of staining in wobbler spinal cords was markedly heterogeneous and non-uniform.
TS28: spinal cord dorsal horn Strong 6C Large motor neurons were labeled at a higher intensity than in wild type.
TS28: spinal cord ventral horn Strong 6C Large motor neurons were labeled at a higher intensity than in wild type.
Specimen 6D: postnatal day 21; Vps54wr/Vps54wr (more )
Structure Level Pattern Image Note
TS28: spinal cord cervical region Strong Non-Uniform 6D Increased perinuclear labeling in motor neurons was noted, as well as intense staining in the nucleoplasm.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory