About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:281028 Kiyama T, et al., Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019 Apr 16;27(3):900-915.e5
Assay type: Recombinase reporter
MGI Accession ID: MGI:6781285
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Reporter: alkaline phosphatase
Direct Detection
Assay notes: mice were induced with i.p. injection (1-5x) of tamoxifen or injected into the vitreous of the right eye four days before sampling
Results
Specimen Fig2B: postnatal; Pou4f1tm2.1Nat/Pou4f1+, Tbr1tm1.1(cre/ERT2)Maoc/Tbr1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina Present Single cells 2B in RGCs with with either asymmetrically distributed dendritic arbors or a symmetrical distributed dendritic arbor morphologies
Specimen Fig5C3: postnatal day 30; Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Pou4f1tm2.1Nat/Pou4f1+, Tbr1tm1.1(cre/ERT2)Maoc/Tbr1+ (more )
Note: Conditional mutant. tamoxifen induction at E18.5 and retina collected on P30
Structure Level Pattern Image Note
TS28: retina Present Single cells 5C3 P1>P30 in RGCs
Specimen Fig4: postnatal day 30; Gt(ROSA)26Sortm2Nat/Gt(ROSA)26Sor+, Tbr1tm1.1(cre/ERT2)Maoc/Tbr1+ (more )
Note: Conditional mutant. 4-OHT was injected into the right eye
Structure Level Pattern Image Note
TS28: dorsal lateral geniculate nucleus Strong 4C , 4D , 4E , 4B more in contralateral side (B, C) than ipsilateral side(D, E) of tamoxifen induction
TS28: superior colliculus Present 4F
Specimen FigS4: postnatal day 30; Gt(ROSA)26Sortm2Nat/Gt(ROSA)26Sor+, Tbr1tm1.1(cre/ERT2)Maoc/Tbr1+ (more )
Note: Conditional mutant. 4-OHT was injected into the right eye
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Absent S4A
TS28: dorsal lateral geniculate nucleus Strong S4D , S4B , S4E , S4C
TS28: superior colliculus Present S4I , S4F , S4H , S4G more in contralateral side than ipcilateral side of tamoxifen induction
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory