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Gene Expression Data
Assay Details
Assay
Reference: J:309394 Kwon HJ, et al., Hippo pathway/Yap regulates primary enamel knot and dental cusp patterning in tooth morphogenesis. Cell Tissue Res. 2015 Nov;362(2):447-51
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6764471
Gene symbol: Yap1
Gene name: yes-associated protein 1
Antibody: anti-Yap
Results
Specimen 1g: embryonic day 13.5 (more )
Note: Double labeled: green - Yap1; red - TOPRO-3.
Structure Level Pattern Image Note
TS21: tooth bud Present Regionally restricted 1g At bud stage, expression in basal cell layer of dental epithelium.
TS21: tooth epithelium Present Regionally restricted 1g At bud stage, expression in basal cell layer of dental epithelium.

Specimen 1h: embryonic day 14.5 (more )
Note: Double labeled: green - Yap1; red - TOPRO-3.
Structure Level Pattern Image Note
TS22: cap stage tooth Present Regionally restricted 1h At cap stage, nuclear expression (co-expression with TOPRO-3) in pattern similar to that of Ki67.

Specimen 1h': embryonic day 14.5 (more )
Note: Double labeled: green - Yap1; red - TOPRO-3.
Structure Level Pattern Image Note
TS22: primary enamel knot Weak Regionally restricted 1h' In primary enamel knot (PEK), expression reduced in cytoplasm and completely absent from nucleus.

Specimen 1i: embryonic day 16.5 (more )
Note: Double labeled: green - Yap1; red - TOPRO-3.
Structure Level Pattern Image Note
TS24: bell stage tooth Present Regionally restricted 1i At bell stage, authors report expression profile similar to those in primary enamel knot at cap stage.

Specimen 1i': embryonic day 16.5 (more )
Note: Double labeled: green - Yap1; red - TOPRO-3.
Structure Level Pattern Image Note
TS24: secondary enamel knot Weak Regionally restricted 1i' In secondary enamel knot (SEK), no nuclear expression.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory