Lhx1 In situ reporter (knock in) Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:208898 Huang CC, et al., Lhx1 is required in Mullerian duct epithelium for uterine development. Dev Biol. 2014 May 15;389(2):124-36
Assay type:	In situ reporter (knock in)
MGI Accession ID:	MGI:6752603
Gene symbol:	Lhx1
Gene name:	LIM homeobox protein 1

Reporter:	lacZ
	Direct Detection

Results

3A ©

Specimen 3A: embryonic day 12.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr (more

)

Structure	Level	Pattern	Image	Note
TS20: nephric duct	Present	Regionally restricted	3A	Mullerian ducts have elongated caudally ~2/3rds the length of Wolffian ducts.
TS20: paramesonephric duct	Present		3A

3B ©

Specimen 3B: embryonic day 12.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr, Tg(Wnt7a-EGFP/cre)#Bhr/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: nephric duct	Present	Regionally restricted	3B	Mullenan ducts have only elongated <25% the length of Wolffian ducts.
TS20: paramesonephric duct	Present		3B

3C ©

Specimen 3C: embryonic day 13.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr (more

)

Structure	Level	Pattern	Image	Note
TS21: nephric duct	Present	Regionally restricted	3C	Mullerian ducts complete formation by connecting to urogenital sinus.
TS21: urogenital sinus	Present	Regionally restricted	3C	Mullerian ducts complete formation by connecting to urogenital sinus.
TS21: paramesonephric duct	Present		3C

3D ©

Specimen 3D: embryonic day 13.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr, Tg(Wnt7a-EGFP/cre)#Bhr/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: nephric duct	Present		3D	Mullerian ducts truncated compared to controls and not connected to urogenital sinus.
TS21: paramesonephric duct	Present		3D

3E ©

Specimen 3E: embryonic day 14.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr (more

)

Structure	Level	Image	Note
TS22: metanephros	Strong	3E	Strong expression in Mullerian ducts, Wolffian ducts and kidneys.
TS22: nephric duct	Strong	3E	Strong expression in Mullerian ducts, Wolffian ducts and kidneys.
TS22: paramesonephric duct	Strong	3E	Strong expression in Mullerian ducts, Wolffian ducts and kidneys.

3F ©

Specimen 3F: embryonic day 14.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr, Tg(Wnt7a-EGFP/cre)#Bhr/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS22: nephric duct	Present	Regionally restricted	3F	Only rostral part of Mullerian ducts have formed.
TS22: metanephros	Present		3F	Woffian ducts and kidneys not affected.
TS22: paramesonephric duct	Present		3F	Woffian ducts and kidneys not affected.

3G ©

Specimen 3G: embryonic day 16.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr (more

)

Structure	Level	Pattern	Image	Note
TS24: nephric duct	Weak	Regionally restricted	3G	Reduced expression in Mullerian ducts with fusion at sinus tip.
TS24: metanephros	Present		3G
TS24: paramesonephric duct	Present		3G

3H ©

Specimen 3H: embryonic day 16.5; Lhx1^tm1Bhr/Lhx1^tm2.1Bhr, Tg(Wnt7a-EGFP/cre)#Bhr/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS24: nephric duct	Present	Regionally restricted	3H	Mullerian duct elongation stops immediately caudal to gonads.
TS24: metanephros	Present		3H
TS24: paramesonephric duct	Present		3H

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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