Irs4 Recombinase reporter Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:299851 Sutton AK, et al., Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance. Sci Rep. 2020 Mar 26;10(1):5546
Assay type:	Recombinase reporter
MGI Accession ID:	MGI:6720265
Gene symbol:	Irs4
Gene name:	insulin receptor substrate 4

Reporter:	GFP
	Direct Detection
Assay notes:	mice were stereotaxically injected in the PVH with a Cre-dependent GFP reporter virus (AAV-Flex-GFP)

Results

1D ©

1D" ©

1D' ©

Specimen Fig1D: postnatal week 8-16; Irs4^{tm1.1(cre)Dolsn}/Y (more

)

Structure	Level	Pattern	Image	Note
TS28: paraventricular hypothalamic nucleus	Present		1D , 1D" , 1D'	in neurons but do not substantially overlap with OXT expressing neurons

1E ©

1E" ©

1E' ©

Specimen Fig1E: postnatal week 8-16; Irs4^{tm1.1(cre)Dolsn}/Y (more

)

Structure	Level	Pattern	Image	Note
TS28: paraventricular hypothalamic nucleus	Present		1E" , 1E , 1E'	in neurons separate from the Nos1 expressing neurons

1F ©

1F" ©

1F' ©

Specimen Fig1F: postnatal week 8-16; Irs4^{tm1.1(cre)Dolsn}/Y (more

)

Structure	Level	Pattern	Image	Note
TS28: paraventricular hypothalamic nucleus	Present		1F" , 1F' , 1F	in neurons but do not substantially overlap with copeptin, the carrier molecule for AVP, expressing neurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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