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Gene Expression Data
Assay Details
Assay
Reference: J:160668 Yang H, et al., Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion. Genesis. 2010 Apr 13;48(6):400-406
Assay type: Recombinase reporter
MGI Accession ID: MGI:6716001
Gene symbol: Gfi1
Gene name: growth factor independent 1 transcription repressor
Reporter: lacZ
Direct Detection
Results
Specimen E13.5: embryonic day 13.5; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lateral semicircular canal Present 2a'
TS21: utricle Present 2b'
TS21: saccule Present 2c'
TS21: cochlea Absent 3a'
Specimen E14.5: embryonic day 14.5; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: lateral semicircular canal Present 2d'
TS22: macula of utricle Present 2d'
TS22: saccule Present 2e'
TS22: cochlea Absent 3b'
Specimen E15.5: embryonic day 15.5; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: macula of utricle Present 2f'
TS23: lateral semicircular canal Present 2f''
TS23: saccule Present 2g'
TS23: cochlea Present 3c'
TS23: thymus primordium Strong 5b
Specimen E16.5: embryonic day 16.5; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lateral semicircular canal Present 2h'
TS24: macula of utricle Present 2h'
TS24: saccule Present 2i'
TS24: cochlea Present 3d' expressed in hair cells of the basal and middle cochlea but not in the apex
Specimen E17.5: embryonic day 17.5; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: saccule Strong 2j'
TS25: lateral semicircular canal Strong 2k'
TS25: cochlea Strong 3e' identified in both the inner and outer hair cells at this stage
Specimen P0: postnatal day 0; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: saccule Present 2l' observed only at the middle and basal turns but not the apex
Specimen P4: postnatal day 4; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cochlea Strong 3f' reactivity in hair cells of the entire cochlea
TS28: vestibulocochlear nerve Absent 3f' no reactivity in the cochleovestibular ganglion
Specimen E13.0: embryonic day 13.0; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: thymus primordium Strong 5a
Specimen P2: postnatal day 2; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: olfactory epithelium Present 5k
Specimen E15.5 section: embryonic day 15.5; Gfi1tm1(cre)Gan/Gfi1+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: thymus primordium Present 5d
TS23: liver Present 5f
TS23: heart Present 5d
TS23: bladder Present 5e
TS23: metanephros Present 5e
TS23: dorsal root ganglion Present 5g
TS23: choroid plexus Present 5c
TS23: skin Present 5d , 5g
TS23: oral region Present 5h upper and lower mouth area
TS23: mandible Present 5h
TS23: maxilla Present 5h
TS23: tongue Present 5i
TS23: gut Present 5j
TS23: lung Present 5l , 5j
TS23: pancreas Present 5j
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory