Acvr1 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:302550 Towler OW, et al., Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP). Dev Biol. 2021 Feb;470:136-146
Assay type:	RNA in situ
MGI Accession ID:	MGI:6696110
Gene symbol:	Acvr1
Gene name:	activin A receptor, type 1

Probe:	Acvr1 probe1
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

S5A ©

Specimen S5A: embryonic day 12.5 (more

)

Structure	Level	Image
TS20: forelimb digit 1	Strong	S5A
TS20: forelimb digit 2	Strong	S5A
TS20: forelimb digit 3	Strong	S5A
TS20: forelimb digit 4	Strong	S5A
TS20: forelimb digit 5	Strong	S5A
TS20: forelimb interdigital region	Present	S5A

S5B ©

Specimen S5B: embryonic day 12.5 (more

)

Structure	Level	Image
TS20: hindlimb digit 1	Strong	S5B
TS20: hindlimb digit 2	Strong	S5B
TS20: hindlimb digit 3	Strong	S5B
TS20: hindlimb digit 4	Strong	S5B
TS20: hindlimb digit 5	Strong	S5B
TS20: hindlimb interdigital region	Present	S5B

S5E ©

Specimen S5E: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: forelimb digit 1	Present	Regionally restricted	S5E	Expression is more restricted at the periphery.
TS21: forelimb digit 2	Present	Regionally restricted	S5E	Expression is more restricted at the periphery.
TS21: forelimb digit 3	Present	Regionally restricted	S5E	Expression is more restricted at the periphery.
TS21: forelimb digit 4	Present	Regionally restricted	S5E	Expression is more restricted at the periphery.
TS21: forelimb digit 5	Present	Regionally restricted	S5E	Expression is more restricted at the periphery.

S5F ©

Specimen S5F: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: hindlimb digit 1	Present	Regionally restricted	S5F	Expression is more restricted at the periphery.
TS21: hindlimb digit 2	Present	Regionally restricted	S5F	Expression is more restricted at the periphery.
TS21: hindlimb digit 3	Present	Regionally restricted	S5F	Expression is more restricted at the periphery.
TS21: hindlimb digit 4	Present	Regionally restricted	S5F	Expression is more restricted at the periphery.
TS21: hindlimb digit 5	Present	Regionally restricted	S5F	Expression is more restricted at the periphery.

S5I ©

Specimen S5I: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: forelimb digit 1	Present	Regionally restricted	S5I	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: forelimb digit 2	Present	Regionally restricted	S5I	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: forelimb digit 3	Present	Regionally restricted	S5I	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: forelimb digit 4	Present	Regionally restricted	S5I	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: forelimb digit 5	Present	Regionally restricted	S5I	Expression is in the digit tips and immediately peripheral to each digit ray.

S5J ©

Specimen S5J: embryonic day 14.5 (more

)

Structure	Level	Pattern	Image	Note
TS22: hindlimb digit 1	Present	Regionally restricted	S5J	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: hindlimb digit 2	Present	Regionally restricted	S5J	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: hindlimb digit 3	Present	Regionally restricted	S5J	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: hindlimb digit 4	Present	Regionally restricted	S5J	Expression is in the digit tips and immediately peripheral to each digit ray.
TS22: hindlimb digit 5	Present	Regionally restricted	S5J	Expression is in the digit tips and immediately peripheral to each digit ray.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24