Gene Expression Data
Assay Details
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Assay
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Reference:
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J:132023
Hwang CH, et al., Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Hum Mol Genet. 2008 Mar 15;17(6):844-53
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:6690306
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Gene symbol:
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Acan
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Gene name:
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aggrecan
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Results
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Specimen
5E:
embryonic day 17.5
(more  )
Specimen
5E:
(close  )
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Genetic Background:
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C57BL/6J
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: incus |
Present |
Regionally restricted |
5E
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Expression in chondrocytes.
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| TS25: stapes |
Present |
Regionally restricted |
5E
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Expression in chondrocytes.
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Specimen
5G:
embryonic day 17.5
(more )
Specimen
5G:
(close )
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Genetic Background:
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C57BL/6J
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: incus |
Present |
Regionally restricted |
5G
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Expression in chondrocytes.
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| TS25: malleus |
Present |
Regionally restricted |
5G
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Expression in chondrocytes.
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Specimen
5I:
(close )
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Genetic Background:
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B6.129S1-Nogtm1Amc
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Mutant Allele(s):
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Nogtm1Amc/Nogtm1Amc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: incus |
Strong |
Regionally restricted |
5I
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Increased in chondrocyte-associated expression. Ossicles enlarged compared with those of wild type.
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| TS25: malleus |
Strong |
Regionally restricted |
5I
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Increased in chondrocyte-associated expression. Ossicles enlarged compared with those of wild type.
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| TS25: stapes |
Strong |
Regionally restricted |
5I
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Increased in chondrocyte-associated expression. Ossicles enlarged compared with those of wild type.
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Specimen
5K:
(close )
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Genetic Background:
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B6.129S1-Nogtm1Amc
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Mutant Allele(s):
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Nogtm1Amc/Nogtm1Amc
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Age:
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embryonic day 17.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS25: incus |
Strong |
Regionally restricted |
5K
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Increased in chondrocyte-associated expression. Ossicles enlarged compared with those of wild type.
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| TS25: malleus |
Strong |
Regionally restricted |
5K
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Increased in chondrocyte-associated expression. Ossicles enlarged compared with those of wild type.
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Specimen
6A:
embryonic day 16.5
(more )
Specimen
6A:
(close )
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Genetic Background:
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C57BL/6J
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: incus |
Strong |
Regionally restricted |
6A
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Highly expressed in chondrocytes.
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| TS24: malleus |
Strong |
Regionally restricted |
6A
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Highly expressed in chondrocytes.
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| TS24: stapes |
Strong |
Regionally restricted |
6A
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Highly expressed in chondrocytes.
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| TS24: joint of auditory ossicle |
Absent |
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6A
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No expression in chondrocytes of annular ligament, malleoindudal joint and stapedoincudal joint.
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Specimen
S2A:
embryonic day 16.5; Nogtm1Amc/Nog +
(more )
Specimen
S2A:
(close )
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Genetic Background:
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B6.129S1-Nogtm1Amc
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Mutant Allele(s):
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Nogtm1Amc/Nog+
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS24: incus |
Strong |
Regionally restricted |
S2A
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Expression similar to that of wild type.
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| TS24: malleus |
Strong |
Regionally restricted |
S2A
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Expression similar to that of wild type.
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| TS24: stapes |
Strong |
Regionally restricted |
S2A
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Expression similar to that of wild type.
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| TS24: joint of auditory ossicle |
Absent |
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Expression similar to that of wild type.
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Analysis Tools