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Gene Expression Data
Assay Details
Assay
Reference: J:239610 Taniguchi K, et al., Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning. Eur J Hum Genet. 2017 Feb;25(2):208-215
Assay type: RNA in situ
MGI Accession ID: MGI:6513207
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh probe194
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 2a control: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: prosencephalon Present Regionally restricted 2a control Expression is ventral.
Specimen 2a cdKO: embryonic day 9.0; Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: prosencephalon Weak Regionally restricted 2a cdKO Expression is ventral.
Specimen 2a Nodal+/z;cdKO: embryonic day 9.0; Nodaltm1Rob/Nodal+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: prosencephalon Weak 2a Nodal+/z;cdKO Expression is ventral.
Specimen 2a Gli3+/r;cdKO: embryonic day 9.0; Gli3tm1Alj/Gli3+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: prosencephalon Weak 2a Gli3+/r;cdKO Expression is ventral.
Specimen 2a G3+/r;N+/z;cdKO: embryonic day 9.0; Gli3tm1Alj/Gli3+, Nodaltm1Rob/Nodal+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS14: prosencephalon Weak 2a G3+/r;N+/z;cdKO Expression is ventral.
Specimen 2b control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future forebrain Present 2b control bottom , 2b control top Expression is ventral.
Specimen 2b cdKO: embryonic day 9.5; Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: future forebrain Weak Regionally restricted 2b cdKO top , 2b cdKO bottom Expression is ventral.
Specimen 2b Nodal+/z;cdKO: embryonic day 9.5; Nodaltm1Rob/Nodal+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: future forebrain Absent 2b Nodal+/z;cdKO top , 2b Nodal+/z;cdKO bottom
Specimen 2b Gli3+/r;cdKO: embryonic day 9.5; Gli3tm1Alj/Gli3+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: future forebrain Absent 2b Gli3+/r;cdKO top , 2b Gli3+/r;cdKO bottom
Specimen 2b G3+/r;N+/z;cdKO: embryonic day 9.5; Gli3tm1Alj/Gli3+, Nodaltm1Rob/Nodal+, Tgif1tm1Caw/Tgif1tm1Caw, Tgif2tm1Dwot/Tgif2tm1Dwot, Edil3Tg(Sox2-cre)1Amc/Edil3+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: future forebrain Present 2b G3+/r;N+/z;cdKO bottom , 2b G3+/r;N+/z;cdKO top There is a partial restoration of expression in the ventral forebrain in this mutant compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/20/2026
MGI 6.24 		The Jackson Laboratory