Fgf3 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:150712 Yaguchi Y, et al., Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development. Dev Dyn. 2009 Jun 19;238(8):2058-2072
Assay type:	RNA in situ
MGI Accession ID:	MGI:6511209
Gene symbol:	Fgf3
Gene name:	fibroblast growth factor 3

Probe:	Fgf3 probe34
Probe preparation:	Antisense RNA

Results

4A ©

Specimen 4A: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: cerebellum	Present	Regionally restricted	4A	Expression is in cells adjacent to the ventricular zone and cells in the Purkinje cell layer, with the highest expression in the posterior half of the cerebellar anlage.
TS24: cerebellum Purkinje cell cluster	Present		4A

4B ©

Specimen 4B: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: cerebellum	Present	Regionally restricted	4B	Expression is in distinct regions along the mediolateral axis and in the prospective vermis in two stripes that straddled an negative midline region and extended laterally to the approximate edge of the prospective vermis. Expression is strong in the anterior halves.

4C ©

Specimen 4C: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: cerebellum Purkinje cell layer	Strong	Regionally restricted	4C	Expression is strongest in Purkinje cells in the anterior cerebellum.
TS27: cerebellum vermis lobule III	Strong	Regionally restricted	4C	Expression is strongest in Purkinje cells in the anterior cerebellum.
TS27: cerebellum vermis lobule IV	Strong	Regionally restricted	4C	Expression is strongest in Purkinje cells in the anterior cerebellum.
TS27: cerebellum vermis lobule V	Strong	Regionally restricted	4C	Expression is strongest in Purkinje cells in the anterior cerebellum.
TS27: cerebellum vermis lobule VI	Strong	Regionally restricted	4C	Expression is strongest in Purkinje cells in the anterior cerebellum.
TS27: cerebellum vermis lobule VII	Strong	Regionally restricted	4C	Expression is strongest in Purkinje cells in the anterior cerebellum.

4D ©

Specimen 4D: postnatal day 0 (more

)
Note: Double labeled: blue - Fgf3; brown - Lhx1 (assay MGI:6511224).

Structure	Level	Pattern	Image	Note
TS27: cerebellum Purkinje cell layer	Present		4D
TS27: cerebellum granule cell layer	Present	Single cells	4D	Expression is in migrating granule cell precursors.

4E ©

Specimen 4E: postnatal day 0 (more

)
Note: Double labeled: blue - Fgf3; brown - S100b (assay MGI:6511223).

Structure	Level	Pattern	Image	Note
TS27: cerebellum Purkinje cell layer	Present		4E
TS27: cerebellum granule cell layer	Present	Single cells		Expression is in migrating granule cell precursors.

4F ©

Specimen 4F: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: cerebellar hemisphere	Present	Regionally restricted	4F	Expression is in distinct parasagittal domains.
TS27: cerebellum vermis	Present	Regionally restricted	4F	Expression is in distinct parasagittal domains.

4G ©

Specimen 4G: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: cerebellar hemisphere	Present	Regionally restricted	4G	Expression is in distinct parasagittal domains.
TS27: cerebellum vermis	Present	Regionally restricted	4G	Expression is in distinct parasagittal domains.

4H ©

Specimen 4H: postnatal day 7 (more

)

Structure	Level	Pattern	Image	Note
TS28: cerebellum Purkinje cell layer	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum vermis lobule I	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum vermis lobule II	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum vermis lobule III	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum vermis lobule IV	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum vermis lobule V	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum vermis lobule VI	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum vermis lobule VII	Present	Regionally restricted	4H	Expression is in the Purkinje cells of lobules I-VII. Fewer cells in lobules I-III and VIbVII had expression compared with lobules IV-VIa.
TS28: cerebellum external granule cell layer	Present	Regionally restricted	4H	Expression is in granule cell precursors with highest levels in lobules IVIa and IXb-X.

Specimen Table 1 E12.5: embryonic day 12.5 (more

)

Structure	Level	Pattern	Image	Note
TS20: cerebellum primordium	Absent

Specimen Table 1 E16.5: embryonic day 16.5 (more

)

Structure	Level	Pattern	Image	Note
TS24: cerebellum Purkinje cell cluster	Present
TS24: cerebellum ventricular layer	Weak
TS24: cerebellum external granule cell layer	Absent

Specimen Table 1 P0: postnatal day 0 (more

)

Structure	Level	Pattern	Image	Note
TS27: cerebellum Purkinje cell layer	Present
TS27: cerebellum external granule cell layer	Absent
TS27: cerebellum ventricular layer	Absent

Specimen Table 1 P7: postnatal day 7 (more

)

Structure	Level	Pattern	Image	Note
TS28: cerebellum Purkinje cell layer	Present
TS28: cerebellum external granule cell layer	Present
TS28: cerebellum internal granule cell layer	Absent

Specimen Table 1 P21: postnatal day 21 (more

)

Structure	Level	Pattern	Image	Note
TS28: cerebellum Purkinje cell layer	Absent			Including Bergmann glia.
TS28: cerebellum granule cell layer	Absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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